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GenomicsPol II (Rpb3) ChIP-seq in Drosophila melanogaster S2 cells
Control of RNA transcription is critical for the development and homeostasis of all organisms, and can occur at multiple steps of the transcription cycle, including RNA polymerase II (Pol II) recruitment, initiation, promoter-proximal pausing, and elongation. That Pol II accumulates on many promoter...
ORGANISM(S): Drosophila melanogaster 
2012-10-25 | E-GEOD-23542 | biostudies-arrayexpress
TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
TranscriptomicsUpstream Anti-sense Promoters Act as Local Enhancers of Mammalian Protein-coding Genes
Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the function or regulation of these anti-sense promoters or the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent t...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-62151 | biostudies-arrayexpress
GenomicsGlobal Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II
We developed a novel approach to isolate and characterize, at nucleotide-level resolution, the RNAs derived from RNA polymerase II (Pol II) in early elongation complexes. We find that high numbers of these short RNAs are not correlated with gene expression but instead are indicative of promoter-prox...
ORGANISM(S): Drosophila melanogaster 
2009-12-11 | E-GEOD-18643 | biostudies-arrayexpress
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