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TranscriptomicsMerck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity.
This SuperSeries is composed of the following subset Series: GSE22768: Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis GSE22769: Systems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immun...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22822 | biostudies-arrayexpress
TranscriptomicsEndogenous MicroRNA Activity Is Not Affected Following Infection With MicroRNA Controlled Adenovirus
Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines, however uncontrolled virus replication in vulnerable tissues can give pathology and often restricts the use of potent strains. Increased knowledge of tissue-selective m...
ORGANISM(S): Mus musculus 
2011-08-19 | E-GEOD-23854 | biostudies-arrayexpress
TranscriptomicsSystems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vitro analysis
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. To determine whether vaccine-induced changes could be ascribed to cell-intrinsic responses rather than cell population fluxes, fresh ...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22769 | biostudies-arrayexpress
ProteomicsAdenovirus remodeling of the host proteome and of host factors associating with viral genomes
Viral infections are associated with extensive remodeling of the cellular proteome. Viruses encode gene products that manipulate host proteins to redirect cellular processes or subvert antiviral immune responses. One way in which host antiviral proteins antagonize viral infection is by associating w...
ORGANISM(S): Viruses Homo sapiens (Human) 
2021-08-11 | PXD025339 | Pride
Intrinsic defense Dna virus Ipond Virus infection Adenovirus 
TranscriptomicsTranscription profiling of baby rat kidney cells transformed with the non-oncogenic Ad5 E1 or oncogenic Ad12 E1 region, as well as primary untransformed BRK cells
Multiple rat microarrays were used to compare RNA transcript levels from 15,481 genes of baby rat kidney (BRK) cells transformed with the non-oncogenic Ad5 E1 or oncogenic Ad12 E1 region, as well as primary untransformed BRK cells.
ORGANISM(S): Rattus norvegicus 
2008-06-20 | E-MTAB-30 | biostudies-arrayexpress
TranscriptomicsSystems analysis of the Merck Ad5/HIV vaccine reveals robust induction of a core innate immune gene network: in vivo analysis
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. We defined the global early immune response to MRKAd5/HIV by profiling the PBMC transcriptomes from seven Ad5Neg individuals pre- and...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-22768 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse FV env-specific CD4 TCRbeta transgenic cells primed by an Ad5 vector
Comparison of the transcriptional profiles of FV env-specific CD4 TCRbeta transgenic cells primed by an Ad5 vector with those primed by FV and submitted in E-MEXP-2950
ORGANISM(S): Mus musculus 
2014-08-01 | E-MTAB-2210 | biostudies-arrayexpress
ProteomicsGingras_Mui_E4orf4_interactions_P107_V5
This submission includes the mass spectrometry data for the manuscript by Mui et al. (E4orf4 interactome). This submission contains 16 files for E4orf4 WT or mutant interactions from HEK293 cells, acquired on LTQ Orbitrap Velos and LTQ Orbitrap Elite. See the README file within "Methods and Protoc...
ORGANISM(S): Human Adenovirus 5 (ncbitaxon:28285) Homo Sapiens (ncbitaxon:9606) 
2015-03-20 | MSV000079082 | MassIVE
UnknownImmunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naive and adenovirus (Ad5) immune mice.
Not available
S-EPMC3472263 | biostudies-literature
UnknownBaseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.
Not available
S-EPMC2723179 | biostudies-literature
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