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TranscriptomicsTranscription profiling of mouse adult primary neural stem cells when stimulated with the proliferative agent PACAP (pituitary adenylate cyclase-activating polypeptide)
Investigation of transcriptional changes induced in adult primary neural stem cells when stimulated with the proliferative agent PACAP (pituitary adenylate cyclase-activating polypeptide). In addition the data was compared to results obtained from a proliferation control (stimulation with a transmem...
ORGANISM(S): Mus musculus 
2005-05-15 | E-MEXP-322 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Bordetella bronchiseptica strains 253 and RB50 to investigate adenylate cyclase toxin (ACT) expression
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B. ...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1203 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Bordetella bronchiseptica strains 253 and RB50 to investigate the cya adenylate cyclase toxin (ACT) operon
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1205 | biostudies-arrayexpress
ProteomicsPhosphoproteomics of cAMP signaling of adenylate cyclase toxin in mouse dendritic cells
The whooping cough agent, Bordetella pertussis, subverts dendritic cell (DCs) functions through powerful immunomodulatory activities of its toxins. Here we focused on the signaling action of the adenylate cyclase toxin (CyaA) that targets myeloid cells expressing the αMβ2 integrin CD11b/CD18 (known ...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-29 | PXD004733 | Pride
Adenylate cyclase toxin Bone marrow-derived dendritic cells Bordetella pertussis Phosphoproteome 
TranscriptomicsTranscriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis
Three different recombinant forms of CyaA were used to investigate transcriptional responses of murine bone marrow-derived macrophages (BMDMs) using Affymetrix Mouse Genome Genechips. These forms were enzymically active, invasive CyaA, nonenzymically active, invasive CyaA (CyaA*) and non-enzymically...
ORGANISM(S): Mus musculus 
2013-09-22 | E-GEOD-51075 | biostudies-arrayexpress
GenomicsAdenylate cyclase-deficient mutant of Corynebacterium glutamicum
Corynebacterium glutamicum GlxR suppressor mutant of adenylate cyclase (cyaB) deletion strain
PRJEB36438 | ENA
ProteomicsProteome-wide analysis of S. cerevisiae controlled by the optogenetic cell cycle regulator bPAC (photo activatable adenylate cyclase from Beggiatoa)
The field of optogenetics offers a powerful toolbox to control cellular processes. We used the photo activatable adenylate cyclase from Beggiatoa to restrict cell-cycle progression under specific light conditions. In a label-free proteomics experiment we investigated the influence of cell-cycle rest...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-24 | PXD046730 | Pride
Yeast light control degradation 
ProteomicsRetargeting from CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzymetranslocating segment of Bordetella adenylate cyclase toxin
The Bordetella adenylate cyclase toxinhemolysin (CyaA) and the α-hemolysin (HlyA) of Escherichia coli both belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins. HlyA preferentially binds the αLβ2 integrin LFA-1 (CD11a/CD18) of leukocytes and can promiscuously bind and per...
ORGANISM(S): Escherichia coli Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-05-11 | PXD018789 | Pride
Ac domain translocation Fatty acyl Rtx toxin Acylation Acyltransferase Integrin 
TranscriptomicsExpression data from Shewanella oneidensis MR-1 wild-type, Δcrp, and ΔcyaC strains
Anaerobic respiration in the metal reducer Shewanella oneidensis MR-1, unlike other bacteria, is regulated by the cAMP receptor protein, CRP. Three putative genes, cyaA, cyaB, and cyaC, predicted to encode class I, class IV, and class III adenylate cyclases respectively, have been identified in the ...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-06-19 | E-GEOD-15657 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of deletion of adenylate cyclase in T. reesei upon growth on cellulose in light and darkness
The aim of this study was to evaluate changes in the transcriptome due to the lack of adenylate cyclase in light or darkness. As the cAMP pathway represents an output pathway of heterotrimeric G-protein signaling ACY1 is likely to be important for regulation of enzymes in response to different nutri...
ORGANISM(S): Trichoderma reesei 
2014-01-08 | E-GEOD-53874 | biostudies-arrayexpress
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