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In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025870 | Pride
To elucidate potential mechanisms how EPB41L5 modulates integrin adhesion complex maturation, we performed quantitative SILAC-based integrin adhesome proteomics. For MS analysis of the podocyte adhesome, EPB41L5 or Luciferase (as negative control) was transient expressed in SILAC labeled podocytes b...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD023821 | Pride
Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis I
Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis II
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry and topological organisation of proteins within IACs are not fully understood. To address ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD017241 | Pride
Exposure of macrophages to oxLDL in vitro or to oxidized lipids-rich milieu of atherosclerotic lesions induces dysregulation of multiple cellular processes including adhesome-dependent functions. Kindlin3 (K3) is indispensable for integrin activation and is directly involved in all adhesome-dependen...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE254743 | GEO
Exposure of macrophages to oxLDL in vitro or to oxidized lipids-rich milieu of atherosclerotic lesions induces dysregulation of multiple cellular processes including adhesome-dependent functions. Kindlin3 (K3) is indispensable for integrin activation and is directly involved in all adhesome-dependen...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE254744 | GEO
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