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TranscriptomicsGene regulation by full length human adiponectin
Transcriptionnal profiling of 4 human cell lines treated during 3 hours with human adiponectin Keywords: transcriptionnal analysis Four human cell lines (Hela, HepG2, Panc-1, Hek293) were grown until confluence. These cell lines were serum depleted during 2 hours and then treated with human adipone...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-14070 | biostudies-arrayexpress
TranscriptomicsAdiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism.
The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA-Seq. Comparing to WT mice, adiponectin KO mice exhibited decreased mRNA expression of rate-...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-38144 | biostudies-arrayexpress
TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in macrophages stimulated 18 h with Adiponectin
Bone marrow derived macrophages (BMDM) generated from c57bl/6j mice bone marrow cells were stimulated for 18 h with 12 microgram/ml adiponectin, RNA from non-stimulated or 18 h adiponectin-stimulated BMDM subjected to a agilent microarray analysis Three different non-stimulated and 3 different 1...
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-49332 | biostudies-arrayexpress
ProteomicsAdiponectin influences the behavior of stem cells in hormone-resistant breast cancer
Overcoming endocrine-resistance is the major challenge in treating Estrogen receptor (ER)-positive breast cancer. Breast Cancer Stem Cells (BCSCs) are blamed to be the driving force behind poor clinical outcomes and therapeutic resistance. Tumor microenvironment (TME) exerts a selective pressure on ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059964 | Pride
Breast cancer Endocrine resistance Cancer stem cells : adiponectin Tamoxifen 
TranscriptomicsEffect of adiponectin deficiency on pulmonary responses to subacute ozone exposure in mice
Adiponectin is an adipose-derived hormone with anti-inflammatory activity. Following subacute ozone exposure (0.3 ppm for 24-72 h), pulmonary neutrophilic inflammation is augmented in adiponectin deficient mice. The purpose of this study was to use microarrays to examine the impact of adiponectin ...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-50183 | biostudies-arrayexpress
TranscriptomicsAdiponectin improves local lipid metabolism in regenerating pancreatic islets after β-cell ablation
Pathways that stimulate β-cell regeneration remain of great clinical interest, yet effective therapeutic avenues that promote survival or reconstitution of β-cell mass remain elusive. Utilizing a mouse model with inducible β-cell apoptosis followed by adiponectin-mediated regeneration, we aimed to i...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64787 | biostudies-arrayexpress
TranscriptomicsUncoupling effects of ERalfa on LKB1/AMPK interaction upon adiponectin exposure in breast cancer
Adipose tissue is a metabolic and endocrine organ that secretes numerous bioactive molecules called adipocytokines. Among these, adiponectin has been argued to have a crucial role in obesity-associated breast cancer. The key molecule of adiponectin signaling is AMP-activated protein kinase (AMPK), m...
ORGANISM(S): Homo sapiens 
2020-02-27 | E-MTAB-6120 | biostudies-arrayexpress
GenomicsSignaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission
Signaling between mammalian adiponectin and a mosquito adiponectin receptor reduces Plasmodium transmission
PRJNA817525 | ENA
TranscriptomicsExpression data from bone marrow cultures treated with adiponectin - evidence for lipopolysaccharide contamination
The adipocyte-derived hormone adiponectin potently inhibits osteoclast formation in vitro. Gene expression profiling of murine bone marrow cells treated with adiponectin was used to identify candidate genes that mediate the effect of adiponectin to inhibit osteoclastogenesis in these cultures. Howev...
ORGANISM(S): Mus musculus 
2012-02-02 | E-GEOD-35466 | biostudies-arrayexpress
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