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UnknownA comprehensive case study of deep learning on the detection of alpha thalassemia and beta thalassemia using public and private datasets.
This study explores the performance of deep learning models, specifically Convolutional Neural Networks (CNN) and XGBoost, in predicting alpha and beta thalassemia using both public and private datasets. Thalassemia is a genetic disorder that impairs hemoglobin production, leading to anemia and othe...
S-EPMC12006322 | biostudies-literature
UnknownFlunarizine as a potential repurposed drug for the serotonin transporter inhibition: an integrated approach for therapeutic development against major depressive disorder.
Major depressive disorder (MDD) is a serious neuropsychiatric condition that affects millions of people worldwide, causing significant psychological distress and lifestyle deterioration. The serotonin transporter, which plays a critical role in regulating the uptake of serotonin (5-HT) back into pre...
S-EPMC12120357 | biostudies-literature
UnknownStructure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder.
The global burden of major depressive disorder (MDD) drives ongoing efforts to develop safer and more targeted treatment strategies. Modern advances have identified trace amine-associated receptor 1 (TAAR1) as a promising non-monoaminergic target with demonstrated efficacy in treating neuropsychiatr...
S-EPMC12324101 | biostudies-literature
UnknownDifferential Gene Expression and Weighted Correlation Network Dynamics in High-Throughput Datasets of Prostate Cancer.
Precision oncology is an absolute need today due to the emergence of treatment resistance and heterogeneity among cancerous profiles. Target-propelled cancer therapy is one of the treasures of precision oncology which has come together with substantial medical accomplishment. Prostate cancer is one ...
S-EPMC9198298 | biostudies-literature
UnknownA structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy.

Background

Dystrophin is a key protein encoded by the DMD gene, serves as a scaffold linking the cytoskeleton to the extracellular matrix that plays a critical role in muscle contraction, relaxation, and structural integrity. Mutations, particularly single-point amino acid substitutio...
S-EPMC11841421 | biostudies-literature
UnknownComparative analysis of web-based programs for single amino acid substitutions in proteins.
Single amino-acid substitution in a protein affects its structure and function. These changes are the primary reasons for the advent of many complex diseases. Analyzing single point mutations in a protein is crucial to see their impact and to understand the disease mechanism. This has given many bio...
S-EPMC9067658 | biostudies-literature
UnknownDiscovering Tuberosin and Villosol as Potent and Selective Inhibitors of AKT1 for Therapeutic Targeting of Oral Squamous Cell Carcinoma.
Oral squamous cell carcinoma (OSCC) is a major cause of death in developing countries because of high tobacco consumption. RAC-alpha serine-threonine kinase (AKT1) is considered as an attractive drug target because its prolonged activation and overexpression are associated with cancer progression an...
S-EPMC9322152 | biostudies-literature
UnknownImpact of Single Amino Acid Substitutions in Parkinsonism-Associated Deglycase-PARK7 and Their Association with Parkinson's Disease.
Parkinsonism-associated deglycase-PARK7/DJ-1 (PARK7) is a multifunctional protein having significant roles in inflammatory and immune disorders and cell protection against oxidative stress. Mutations in PARK7 may result in the onset and progression of a few neurodegenerative disorders such as...
S-EPMC8878504 | biostudies-literature
UnknownThe Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography.

Background and objectives

Contrast-associated AKI may result in higher morbidity and mortality. Intravenous fluid administration remains the mainstay for prevention. There is a lack of consensus on the optimal administration strategy. We studied the association of periprocedure fluid adminis...
S-EPMC9528263 | biostudies-literature
UnknownGlobal, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Background

Although meningitis is largely preventable, it still causes hundreds of thousands of deaths globally each year. WHO set ambitious goals to reduce meningitis cases by 2030, and assessing trends in the global meningitis burden can help track progress and identify gaps in achieving t...
S-EPMC10356620 | biostudies-literature
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