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TranscriptomicsDisruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndrome [multi-omic]
Here, to characterize HVDAS in a developmental setting, we generated cortical brain organoids of 5 control and 5 HVDAS lines and profiled them by single-cell RNA- and ATAC-seq. Organoids were grown for 30 days using the protocol 10.1016/j.stem.2019.08.002. To reduce batch effects and costs, and maxi...
ORGANISM(S): Homo sapiens 
2026-01-27 | E-MTAB-16422 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ADNP knockout vs wild type
The putative transcription factor, activity-dependent neuroprotective protein (ADNP) is a zinc finger and homeodomain - like profile containing protein. ADNP knockout mice die at day 9 of gestation. To reveal ADNP-associated pathways, a 22,690- Affymetrix probe array was used on ADNP knockout and co...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4068 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis of ADNP-mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory along with social and anxiety-related deficits in adults, long after the juvenile-stag...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-11 | PXD037325 | Pride
Phosphoproteomics Autism spectrum disorder Adnp syndrome Lc-ms/ms 
GenomicsDisruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndrome [ ChIP-seq ]
This work attempt at characterizing the DNA binding activity of ADNP in healthy lines, HVDAS lines, and ADNP KO lines. We profiled also the epigenomic landscape of the same lines, to reconstruct the molecular basis of HVDAS at early stages of neurodevelopment. We performed ChIP-seq of active enhance...
ORGANISM(S): Homo sapiens 
2026-01-26 | E-MTAB-16527 | biostudies-arrayexpress
ProteomicsProteomic analysis of Adnp mutant mice
We report age-differential synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIa hyperactivity in Adnp-mutant mice. These mice show impaired and inflexible contextual learning and memory additional to social and anxiety-related deficits in adults long after a marked decrea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090257 | MassIVE
TranscriptomicsDisruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndrome
Our experimental workflow was designed to study the role of ADNP in pluripotency and neuronal differentiation. Collectivelty, we profiled 12 iPSC, 2 NSC and 10 cortical brain organoids lines. This dataset contains RNA-seq profiling of iPSC and NSC, respectively capturing patient-derived transcriptio...
ORGANISM(S): Homo sapiens 
2026-01-31 | E-MTAB-15963 | biostudies-arrayexpress
UnknownPremature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children.
Not available
S-EPMC5438031 | biostudies-literature
UnknownSensory Reactivity Symptoms Are a Core Feature of ADNP Syndrome Irrespective of Autism Diagnosis.
Not available
S-EPMC7997330 | biostudies-literature
GenomicsChIP-seq of ADNP and TRIM28 in the U2OS cell line (Human Bone Osteosarcoma Epithelial Cells)
In order to investigate the functions of the zinc finger transcription regulator ZMYM2 and the different types of ZMYM2 binding complex with TRIM28 or ADNP, we generated the ChIP-seq data of ADNP or TRIM28 in U2OS cells.
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12292 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the U2OS cell line (Human Bone Osteosarcoma Epithelial Cells) treated with ZMYM2, TRIM28 or ADNP knock down against the control conditions.
In order to investigate the functions of the zinc finger transcription regulator ZMYM2 and the different types of ZMYM2 binding complex with TRIM28 or ADNP, we generated the RNA-seq data with ZMYM2, TRIM28 or ADNP siRNA in U2OS cells and the control cases with siNT in U2OS cells as well.
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12291 | biostudies-arrayexpress
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