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ProteomicsIdentification of proteins that interact with TRAF6 in ADP-heptose- or IL-1β-stimulated HEK293 cells
The bacterial metabolite ADP-heptose activates the mammalian protein kinase ALPK1 (alpha protein kinase 1), which then phosphorylates TIFA (TRAF interacting protein with FHA domain). This leads to the oligomerisation of TIFA and the recruitment and oligomerisation of TRAF6 (TNF receptor-associated f...
ORGANISM(S): Homo sapiens (Human) 
2022-09-14 | PXD034964 | Pride
Adp-heptose Traf6 Tifa Alpk1 
TranscriptomicsTifa-/- vs Tifa+/+ small intestinal organoids stimulated with water, IL-22, IL-22+ADP-Heptose
Bulk RNA sequencing of small intestinal organoids obtained from germline Tifa-/- versus wild-type littermate control mice stimulated in vitro with IL-22 or IL-22 plus ADP-heptose versus mock control
ORGANISM(S): Mus musculus 
2025-05-01 | E-MTAB-14831 | biostudies-arrayexpress
GenomicsTifa-/- vs Tifa+/+ small intestinal organoids stimulated with water, IL-22, IL-22+ADP-Heptose
Tifa-/- vs Tifa+/+ small intestinal organoids stimulated with water, IL-22, IL-22+ADP-Heptose
PRJEB85839 | ENA
GenomicsBacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [RNA-seq]
Bacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [RNA-seq]
PRJNA1265132 | ENA
GenomicsBacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [scRNA-seq]
Bacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [scRNA-seq]
PRJNA1265136 | ENA
ProteomicsADP-heptose attenuates H. pylori-induced type I IFN signaling in DCs and impairs subsequent T cell responses
Helicobacter pylori (H. pylori) colonizes the gastric mucosa of approximately 50% of the world’s population. While it is well established that H. pylori is a major cause of gastric cancer, it has only recently been reported that H. pylori can also have adverse effects on immunological processes, in...
ORGANISM(S): Homo sapiens (Human) 
2024-09-13 | PXD046603 | Pride
Shotgun proteomics Cd8 Adp heptose Label-free quantification H. pylori 
TranscriptomicsBacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [scRNA-seq]
ADP-Heptose (ADP-Hep), a metabolite produced by Gram-negative bacteria as an intermediate of lipopolysaccharide biosynthesis, is detected in the host cytosol by the kinase ALPK1, which engages TIFA-dependent innate immune responses. However, the functional role of the ALPK1-TIFA pathway in the intes...
ORGANISM(S): Mus musculus 
2025-08-18 | GSE297524 | GEO
TranscriptomicsBacterial ADP-Heptose triggers stem cell regeneration in the intestinal epithelium following injury [RNA-seq]
ADP-Heptose (ADP-Hep), a metabolite produced by Gram-negative bacteria as an intermediate of lipopolysaccharide biosynthesis, is detected in the host cytosol by the kinase ALPK1, which engages TIFA-dependent innate immune responses. However, the functional role of the ALPK1-TIFA pathway in the intes...
ORGANISM(S): Mus musculus 
2025-08-18 | GSE297523 | GEO
UnknownADP-heptose attenuates Helicobacter pylori-induced dendritic cell activation.
Not available
S-EPMC11409497 | biostudies-literature
UnknownCharacterization of the ADP-β-D-manno-heptose biosynthetic enzymes from two pathogenic Vibrio strains.
Not available
S-EPMC10948575 | biostudies-literature
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