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TranscriptomicsTraf6 function in the innate immune response of zebrafish embryos
Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. Two-way factorial dual colour design with factor 1 'infection with Salmonella ...
ORGANISM(S): Danio rerio 
2010-08-01 | E-GEOD-20310 | biostudies-arrayexpress
TranscriptomicsTraf6 function in the innate immune response of zebrafish embryos
Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. All infection experiments were performed using mixed egg clutches of ABxTL str...
ORGANISM(S): Danio rerio 
2010-08-01 | E-GEOD-21024 | biostudies-arrayexpress
ProteomicsIdentification of proteins that interact with TRAF6 in ADP-heptose- or IL-1β-stimulated HEK293 cells
The bacterial metabolite ADP-heptose activates the mammalian protein kinase ALPK1 (alpha protein kinase 1), which then phosphorylates TIFA (TRAF interacting protein with FHA domain). This leads to the oligomerisation of TIFA and the recruitment and oligomerisation of TRAF6 (TNF receptor-associated f...
ORGANISM(S): Homo sapiens (Human) 
2022-09-14 | PXD034964 | Pride
Adp-heptose Traf6 Tifa Alpk1 
TranscriptomicsTranscription profiling of mouse CD8 T cells from two mouse strains (OTI-WT and OTI-TRAF6 knockout) at two timepoints
CD8 T cells play a crucial role in immunity to infection and cancer. They are maintained in constant numbers, but upon stimulation with antigen undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific populations, followed ...
ORGANISM(S): Mus musculus 
2009-06-24 | E-GEOD-15750 | biostudies-arrayexpress
ProteomicsProteome profile of Traf6-OE OT-I T cells
Proteome profile of Traf6-OE OT-I T cells and EV OT-I cells after viral transfection
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039327 | Pride
Mouse Lc-ms Traf6-oe ot-i t cells 
TranscriptomicsTranscriptome analysis of Traf6 function in early zebrafish embryogenesis
In order to study Traf6 function during early zebrafish embryogenesis, transcriptome expression profiling was performed at 30% epiboly using a morpholino based knock-down approach. Two-factorial design with the factors 'Treatment' (5 levels:'Phenol Red', 'Standard Control', 'Mismatch', 'Morpholino1'...
ORGANISM(S): Danio rerio 
2013-12-01 | E-GEOD-42856 | biostudies-arrayexpress
TranscriptomicsCytotoxic effects of Bortezomib in Myelodysplastic syndrome/Acute Myeloid Leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Bortezomib (VelcadeM-BM-)) is widely used for the treatment of various human cancers, however, its mechanisms of action are not fully understood, particularly in myeloid malignancies. Bortezomib is a selective and reversible inhibitor of the proteasome. Paradoxically, we find that Bortezomib induces...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-38519 | biostudies-arrayexpress
ProteomicsK48/K63-linked polyubiquitination of ATG9A at K581/K838 by TRAF6 E3 ligase
Excessive generation and accumulation of highly reactive oxidizing molecules causes oxidative stress and oxidative damage to cellular components. Accumulating evidence indicates that autophagy diminishes oxidative damage in cells and maintains redox homeostasis by degrading and recycling intracellul...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD030415 | Pride
Ubiquitin Traf6 Atg9a 
GenomicsPlasma protein profiling in human TRAF6 deficiency
Plasma protein profiling in human TRAF6 deficiency
PRJNA1537692 | ENA
ProteomicsREGγ is essential to maintain bone homeostasis by degrading TRAF6, preventing osteoporosis
Primary osteoporosis, manifesting as decreased bone mass and increased bone fragility, is a “silent disease” that is often ignored until a bone breaks. Accordingly, it is urgent to develop reliable biomarkers and novel therapeutic strategies for osteoporosis treatment. Here, we identified REGγ as...
ORGANISM(S): Homo Sapiens 
2024-10-27 | PXD057237 |
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