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MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
ProteomicsK48/K63-linked polyubiquitination of ATG9A at K581/K838 by TRAF6 E3 ligase
Excessive generation and accumulation of highly reactive oxidizing molecules causes oxidative stress and oxidative damage to cellular components. Accumulating evidence indicates that autophagy diminishes oxidative damage in cells and maintains redox homeostasis by degrading and recycling intracellul...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD030415 | Pride
Ubiquitin Traf6 Atg9a 
ProteomicsATG9A is a component of the ESCRT system and governs plasma membrane repair
ATG9 is often described as the sole transmembrane protein among the core autophagy factors. The mammalian ATG9A is notorious for trafficking through numerous cellular compartments including the plasma membrane. The reasons for ATG9As wide intracellular distribution and its role at the PM are not ful...
ORGANISM(S): Homo 
2019-10-30 | MSV000084519 | MassIVE
ProteomicsATG9A TurboID - ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving ER-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P) and oxysterol-binding protein-related proteins (ORPs) li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD056417 | Pride
Arfip2 Membrane trafficking Autophagy Lysosomal damage Lysosome Ap-3 Pi4k2a Atg9a Pi4p 
ProteomicsSynaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Ectopic expression in fibroblasts of synapsin 1 and synaptophysin is sufficient to generate condensates of vesicles highly reminiscent of synaptic vesicle (SV) clusters and with liquid-like properties. We show that unlike synaptophysin, other major integral SV membrane proteins fail to form condensa...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2022-12-24 | PXD037490 | Pride
Synaptophysin Synapsin Atg9a Sypnatic vesicle 
ProteomicsIsolation and mass spectrometry analysis of ATG9A vesicles from HAP1 cells.
Autophagy is a conserved cellular degradation pathway involving the formation of double-membrane autophagosomes that engulf cytoplasmic material for delivery to the lysosome. Autophagy-related (ATG) proteins orchestrate the steps of autophagosome formation and maturation, among which ATG9A is unique...
ORGANISM(S): Homo sapiens (Human) 
2026-08-04 | PXD066668 | Pride
Human Hap1 cells Atg9a vesicles 
ProteomicsGFP-Trap ARFIP2 - ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving ER-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P) and oxysterol-binding protein-related proteins (ORPs) li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD056398 | Pride
Arfip2 Membrane trafficking Autophagy Lysosomal damage Lysosome Ap-3 Pi4k2a Atg9a Pi4p 
TranscriptomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
This study investigates the role of cancer cell surface proteins in modulating the response of cancer cells to macrophage-induced cytotoxicity. Utilizing two targeted CRISPR screens using OVCAR-8 cell line and a targeted CRISPR library for cancer cell surface proteins, ATG9A was identified as a key ...
ORGANISM(S): Homo sapiens Mus musculus 
2025-04-30 | GSE266329 | GEO
GenomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
Co-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
PRJNA1106773 | ENA
ProteomicsAP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic methods, including ‘Dynamic Organellar Maps’, to find proteins whose su...
ORGANISM(S): Homo sapiens (Human) 
2018-09-27 | PXD010103 | Pride
Human cells Autophagy Dynamic organellar maps Ap-4 Vesicles 
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