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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
GenomicsBacillus velezensis strain:AP-3
Bacillus velezensis strain:AP-3 Genome sequencing
PRJNA1392455 | ENA
ProteomicsConformation of the AP-3 complex explains its role in cargo recruitment at the Golgi
Crosslinking mass spectrometry study of an important adapter protein complex at the Golgi AP-3. We performed crosslinking mass spectrometry study using crosslinker DSSO and analyzed the digested peptides by LC-MS. The crosslinking study provided important information the subunit connectivity of AP-3...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-17 | PXD028005 | Pride
Mass spectrometry Structure Ap-3 Crosslinking 
ProteomicsAP-3 vesicles retain their coat and depend on the HOPS subunit Vps41 for tethering to vacuoles
Identification of Age2 as part of AP-3 vesicles using Turbo-ID
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD020623 | Pride
Age2 ap-3 turbo-id 
ProteomicsChemical proteomics of AP-3 in Actinosynnema pretiosum
we use chemoproteomic approach with an AP-3-derived photoaffinity probe to profile the proteome-wide interactions of AP-3.
ORGANISM(S): Actinosynnema pretiosum 
2023-10-24 | PXD043867 | Pride
Actinosynnema pretiosum Ap-3 Chemical proteomics 
Clinical3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma
This phase I trial is studying the best dose of 3-AP and the side effects of giving 3-AP together with gemcitabine in treating patients with advanced solid tumors or lymphoma. Drugs used in chemotherapy, such as 3-AP and gemcitabine (GEM), work in different ways to stop the growth of cancer cells, e...
2026481 | ecrin-mdr-crc
ProteomicsAP-3 cargo - Identification of cargo for adaptor protein complexes AP-3 and AP-4 by sucrose gradient profiling
Identificatoin of cargo protein of AP-3 using metabolic labeling in label-swap experiments
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-07-07 | PXD003905 | Pride
Protein targeting 
GenomicsTranscriptome of Actinosynnema pretiosum ATCC 31280 under exogenous supplement of AP-3
Transcriptome of Actinosynnema pretiosum ATCC 31280 under exogenous supplement of AP-3
PRJNA587649 | ENA
UnknownCalcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.
Not available
S-EPMC3813962 | biostudies-literature
TranscriptomicsTranscriptome of Actinosynnema pretiosum ATCC 31280 under exogenous supplement of AP-3
In search of AP-3 resistant genes, ATCC 31280△ansaA (inactivation of ansamitocin pksA, in avoiding of the interruption of endogenous generated AP-3) were cultured under the addition of 0, 50, 100 and 200 mg/L exogenous AP-3 for 24 h and collected, for strains under 200 mg/L AP-3, samples after 48 h ...
ORGANISM(S): Actinosynnema pretiosum 
2019-11-06 | GSE139930 | GEO
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