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ProteomicsAP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic methods, including ‘Dynamic Organellar Maps’, to find proteins whose su...
ORGANISM(S): Homo sapiens (Human) 
2018-09-27 | PXD010103 | Pride
Human cells Autophagy Dynamic organellar maps Ap-4 Vesicles 
GenomicsRosa canina cultivar:AP-4
DNA barcoding of Rosa canina AP-4
PRJNA893103 | ENA
ProteomicsAP-4 cargo - Identification of cargo for adaptor protein complexes AP-3 and AP-4 by sucrose gradient profiling
Identificatoin of cargo protein of AP-4 using metabolic labeling in label-swap experiments
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-07-07 | PXD003894 | Pride
Adaptor protein complex 4 
ProteomicsCrosslinked AP-4 core/ARF1 complex
This project investigates the architecture of the crosslinked AP-4 core/ARF1 complex using chemical crosslinking coupled with mass spectrometry (XL-MS). The dataset defines inter- and intra-molecular crosslinks to map interaction interfaces, validate structural models, and elucidate the molecular ba...
ORGANISM(S): Homo Sapiens 
2025-12-23 | PXD072343 |
ProteomicsHigh-Content Screening Identifies A Small Molecule That Restores AP-4-dependent Protein Trafficking In Neuronal Models Of AP-4-Associated Hereditary Spastic Paraplegia
Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules that correct aberrant protein trafficking in adaptor protein complex 4 (AP-4) defici...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042950 | Pride
Human Autophagy Ipsc Drug screen Protein trafficking Hsp 
UnknownThe FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.
Not available
S-EPMC7185972 | biostudies-literature
UnknownUncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics.
Not available
S-EPMC12519218 | biostudies-literature
UnknownThe adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits.
Not available
S-EPMC9635299 | biostudies-literature
UnknownAP-4-mediated axonal transport controls endocannabinoid production in neurons.
Not available
S-EPMC8881493 | biostudies-literature
UnknownAP-4 loss in CRISPR-edited zebrafish affects early embryo development.
Not available
S-EPMC9992121 | biostudies-literature
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