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MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
Proteomics,MultiomicsHematopoietic stem cells (HSCs)
G0 marker-separation of dormant and active hematopoietic stem cells reveals dormancy regulation by basal cytoplasmic calcium
ORGANISM(S): Mus Musculus (mouse) 
2019-12-19 | PXD012093 | JPOST Repository
TranscriptomicsHematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
We used comparative transcriptome analysis to determine the relationship between rodent Multipotent Adult Progenitor Cells (MAPCs) and pluripotent embryonic stem cells (ESCs), or lineage restricted mesenchymal stem cells (MSCs) and neurospheres (NS). This comparison revealed a unique gene expression...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-5947 | biostudies-arrayexpress
TranscriptomicsThe transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells
This SuperSeries is composed of the following subset Series: GSE25265: Genome-wide analysis of the binding pattern of the transcriptional co-activator Cbp. GSE25268: The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells Refer to individual S...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25274 | biostudies-arrayexpress
ProteomicsHematopoietic stem cell derived conditioned media metabolomics
Metabolomic data of conditioned media derived from culturing hematopoietic stem cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-14 | MSV000097113 | MassIVE
GenomicsLIM domain binding protein 1 regulates a transcriptional program essential for hematopoietic stem cell maintenance
We used ChIP-Seq to map Ldb1, Scl and Gata2 binding sites in mouse hematopoietic progenitor cells (HPCs). Together with functional studies using conventional and conditional Ldb1 deficient mouse models and bioinformatics analysis, we systematically determined a transcriptional program controlled by ...
ORGANISM(S): Mus musculus 
2011-01-04 | E-GEOD-26031 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells (HSCs), progenitor cells (HPCs), and granulocytes somatic cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer
Since the creation of Dolly, the first sheep cloned via somatic cell nuclear transfer (SCNT), in 1997, more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1-5%) is that the clones are likely derived from adult stem...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5677 | biostudies-arrayexpress
TranscriptomicsExpression data for conditional Dnmt1knockout hematopoietic stem and progenitor cells
DNA methylation is essential for mammalian development and plays crucial roles in a variety of biological processes. The DNA methyltransferase Dnmt1 serves to maintain parental cell methylation patterns on daughter DNA strands in mitotic cells, however, the precise role of Dnmt1 in regulation of qui...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15840 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse multipotent adult progenitor cells (MAPCs), 2 different clones
We compare the transcriptome of two different clones of multipotent adult progenitor cells (MAPCs) using Affymetrix arrays. Experiment Overall Design: Three mRNA samples (biological replicates) per cell type taken at different passage number were compared. Two independently isolated MAPC clones were...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6291 | biostudies-arrayexpress
TranscriptomicsLin28b expression distinguishes fetal versus adult lymphopoiesis
This SuperSeries is composed of the following subset Series: GSE35081: miRNA profiling of double-positive thymocytes transduced with a retrovirus encoding Lin28a compared to untransduced controls GSE35107: microRNA profiling of fetal liver and adult bone marrow pro-B cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-35214 | biostudies-arrayexpress
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