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ProteomicsLarge-scale secretome analyses unveil a superior immunosuppressive phenotype from umbilical cord stromal cells compared to other adult mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) with regenerative and immunomodulatory potential are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express a wide variety of bioactive molecules including cytokines, trophic factors, and proteases, which act in a paracrine fashion to ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-29 | PXD011762 | Pride
Chondrocytes Adult stromal cells Umbilical cord stromal cells Lfq Secretome and immunomodulation 
TranscriptomicsTranscription profiling of mouse primary cultures from mouse cornea vs those of the adult and 10-day postnatal mouse cornea to elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells
To elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells, the gene expression patterns of these primary cultures from mouse cornea were compared with those of the adult and 10-day postnatal mouse cornea.
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-1867 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Resto6 human stromal cells
Resto6 stromal cells support the long-term survival of human plasma cells differentiated in vitro. Whole genome gene expression microarrays made it possible to pick up genes whose products could be involved in a biological pathway inducing long-term survival of plasma cells.
ORGANISM(S): Homo sapiens 
2013-12-11 | E-MTAB-2118 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostatic stromal cells cultured from diseased vs normal tissues
To obtain a comprehensive view of the transcriptional programs in prostatic stromal cells of different histological/pathological origin, we profiled 18 adult human stromal cell cultures from normal transition zone (TZ), normal peripheral zone (PZ), benign prostatic hyperplasia (BPH), and prostate ca...
ORGANISM(S): Homo sapiens 
2006-11-06 | E-SMDB-3867 | biostudies-arrayexpress
TranscriptomicsFibroblastic reticular cells in the spleen - total splenic Stroma cells - single cell RNAseq dataset 2
Splenic white pulp (WP) structures are underpinned by fibroblastic stromal cells (FSCs) to facilitate splenic compartmentalization and execute efficient immune responses. Although distinct WP FSCs exhibit various molecular traits, the origin and the hierarchical differentiation of different cell sub...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7703 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human embryonic stem cells, adult fibroblasts , and CD34+ cord blood (CB) cells before, during, and afer their episomal induction of pluripotency
Global gene expression analysis of (a) human embryonic stem cells, (b) adult fibroblasts with and without nucleofection of SOKM, and ( c ) CD34+ cord blood cells at various time points during induction of pluripotency with SOKM, with or without co-culture with bone marrow stromal cells (BMSC). Total...
ORGANISM(S): Homo sapiens 
2012-08-23 | E-GEOD-35027 | biostudies-arrayexpress
TranscriptomicsMicroarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
The purpose of this experiment was to determine the transcriptional differences between neural progenitor cells from neonatal lung injury mice vs. control mice, as well as neonatal lung injury mice treated with umbilical-cord mesenchymal stromal cell extracellular vesicles vs. neonatal lung injury m...
ORGANISM(S): Mus musculus 
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
TranscriptomicsDirect contact with mesenchymal stromal cells impacts CD133+ hematopoietic stem cells during ex-vivo expansion
Direct contact with mesenchymal stromal impacts on migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex-vivo expansion Objective: To investigate the impact of direct contact between mesenchymal stromal cells (MSCs) and CD133+ hematopoietic stem cells (HSCs) in ...
ORGANISM(S): Homo sapiens 
2008-11-12 | E-GEOD-13566 | biostudies-arrayexpress
TranscriptomicsOrigin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp - single cell RNAseq dataset 1
Splenic white pulp (WP) structures are underpinned by fibroblastic stromal cells (FSCs) to facilitate splenic compartmentalization and execute efficient immune responses. Although distinct WP FSCs exhibit various molecular traits, the origin and the hierarchical differentiation of different cell sub...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7094 | biostudies-arrayexpress
TranscriptomicsCultured human adipose tissue pericytes and mesenchymal stromal cells display a very similar gene expression profile
Mesenchymal stromal cells (MSCs) are cultured cells that can give rise to mature mesenchymal cells under appropriate conditions, and secrete a number of biologically relevant molecules that may play an important role in regenerative medicine. Evidence indicates that pericytes (PCs) correspond to mes...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-67747 | biostudies-arrayexpress
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