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TranscriptomicsTranscription profiling of chicken proliferative and hypertrophic chondrocytes
Longitudinal bone growth depends upon the execution of an intricate series of cellular activities by epiphyseal growth plate chondrocytes. In order to better understand these coordinated events, microarray analysis was used to compare gene expression in chondrocytes isolated from the proliferative a...
ORGANISM(S): Gallus gallus 
2009-10-23 | E-GEOD-18568 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression levels in BBF2H7-/- chondrocytes
BBF2H7 (BBF2 human homolog on chromosome 7), an ER-resident basic leucine zipper transcription factor, is activated in response to ER stress and abundantly expresses in chondrocytes. While BBF2H7 is widely expressed in many tissues and organs, the most intense signals were detected in the proliferat...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-18052 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat chondrocytes treated with glucosamine exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta
Glucosamine proved to be a potent, broad-spectrum inhibitor of IL-1beta. Of the 2,813 genes whose transcription was altered by IL-1beta stimulation (p<0.0001), glucosamine significantly blocked the response in 2,055 (~73%). Glucosamine fully protected the chondrocytes from IL-1-induced expression of...
ORGANISM(S): Rattus norvegicus 
2009-04-23 | E-GEOD-6119 | biostudies-arrayexpress
TranscriptomicsGene expression in control and cilia deleted growth plate chondrocytes
Proliferative zone chondrocytes were microdissected from control and Ift88-deleted growth plates to determine gene expression profiles regulated by primary cilia. Four total samples were analyzed. Two biological replicates of proliferative zone chondrocytes microdissected from control mice and two b...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-35003 | biostudies-arrayexpress
ProteomicsIntegrated molecular phenotyping in chondrocytes identifies genes and pathways disrupted in osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease with a substantial health economic burden. There is no current treatment; instead, disease management targets the main symptoms (pain and stiffness) and culminates in joint replacement surgery. OA is a disease of cartilage degeneration, but the mol...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002014 | Pride
Human Label free Tmt Chondrocytes Osteoarthritis 
TranscriptomicsTranscription profiling of mouse dexamethasone-treated primary chondrocytes identifies downstream targets of glucocorticoid signalling
Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regul...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7683 | biostudies-arrayexpress
TranscriptomicsIn vitro effect of the integrine LAMA4 on motility and cluster formation of human chondrocytes
Background: Cluster formation of hypertrophic chondrocytes is a sign of late stage osteoarthritis. In vitro chondrocytes have the ability to migrate on scaffolds. Important for motility issues in cartilage are integrines, part of the extracellular matrix, important for locomotory stimuli. The integr...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-68428 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling in osmotically stimulated chondrocytes
miRNA analysis of human articular chondrocytes cultured under 380mOsm or 550mOSm conditions for 5 hours.
ORGANISM(S): Homo sapiens 
2011-06-01 | E-MTAB-654 | biostudies-arrayexpress
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063036 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063031 | Pride
Chondrocytes Lysosome Fgf 
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