Af9 - OmicsDI

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Genomics (591)
Transcriptomics (529)
Unknown (334)
Proteomics (28)
Other (10)
Metabolomics (8)
Methylation profiling (4)

Organisms

Mus musculus (409)
Homo sapiens (157)
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Schizophyllum commune H4-8 (19)
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Organisms

Mus musculus (300)
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unidentified (1)

Repository

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Tissue

Bone marrow (9)
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Cells (2)
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Disease

Acute leukemia (10)
Acute myeloid leukemia (3)
Cardiac defects (1)
Embryonal carcinoma (1)
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Technology Type

Mass Spectrometry (22)
Shotgun proteomics (6)
Bottom-up proteomics (5)
Mass spectrometry (4)
ESI (3)
Data-independent acquisition (3)
Affinity purification coupled with mass spectrometry proteomics (3)
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Mass spectrometry assay (1)
MSE (1)
SWATH MS (1)
Top-down proteomics (1)

Instrument Platform

Illumina HiSeq 2500 (11)
Illumina NovaSeq 6000 (6)
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NextSeq 500 (5)
NextSeq 550 (4)
Illumina MiSeq (2)
- (2)
Liquid Chromatography MS - alternating - hilic (2)
Liquid Chromatography MS - negative - hilic (2)
Liquid Chromatography MS - positive - hilic (2)
DNBSEQ G40 (1)
BD Rhapsody Express Instrument (1)
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Sigma-Aldrich (1)
NextSeq 2000 (1)
Illumina HiSeq 1000 (1)
Illumina HiSeq 1500 (1)
Q Exactive (1)
Q-Exactive (Thermo Scientific) (1)
Liquid Chromatography MS - negative (1)
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Liquid Chromatography MS - negative - reverse phase (1)

Publication Date

2015 (80)
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2014 (60)
2013 (48)
2012 (48)
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2019 (33)
2017 (32)
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2024 (30)
2018 (30)
2021 (29)
2011 (29)
2023 (25)
2020 (25)
2026 (24)
2010 (18)
2008 (16)
2009 (12)
2006 (5)
2007 (3)
2005 (2)

UNIPROT ID/AC

A0A1D5PAT2_CHICK (2)
A0A1D5PCQ0_CHICK (2)
A0A3Q3A4R7_CHICK (2)
F1NLZ0_CHICK (2)
AMPH_CHICK (2)
A0A1D5PJ83_CHICK (2)
E1C7L1_CHICK (2)
CXB6_CHICK (2)
A0A1D5NT59_CHICK (2)
F1NUR0_CHICK (2)
PRVU_CHICK (2)
TECTA_CHICK (2)
F1NRL3_CHICK (2)
A0A1D5PR48_CHICK (2)
F1NAE5_CHICK (2)
F1NLZ9_CHICK (2)
9031.ENSGALP00000005497 (2)
F1P0S4_CHICK (2)
F1NU61_CHICK (2)
A0A1D5NXZ7_CHICK (2)
E1BW48_CHICK (2)
F1P194_CHICK (2)
R4GKD4_CHICK (2)
A0A1D5P2W5_CHICK (2)
F1NE64_CHICK (2)
F1NVF2_CHICK (2)
CALB1_CHICK (2)
COCH_CHICK (2)
F1NSL6_CHICK (2)
Q4F8N2_CHICK (2)

CHEBI ID

CHEBI:70749 (2)
CHEBI:27266 (2)
CHEBI:7916 (2)
CHEBI:16359 (2)
CHEBI:16919 (2)
CHEBI:17687 (2)
CHEBI:136162 (1)
CHEBI:194274 (1)
CHEBI:182120 (1)
CHEBI:194273 (1)
CHEBI:113535 (1)
CHEBI:134075 (1)
CHEBI:51686 (1)
CHEBI:74970 (1)
CHEBI:136123 (1)
CHEBI:183014 (1)
CHEBI:176766 (1)
CHEBI:136378 (1)
CHEBI:190528 (1)
CHEBI:134589 (1)
CHEBI:194275 (1)
CHEBI:183780 (1)
CHEBI:167820 (1)
CHEBI:89690 (1)
CHEBI:134595 (1)
CHEBI:64243 (1)
CHEBI:194278 (1)
CHEBI:7989 (1)
CHEBI:192581 (1)
CHEBI:183461 (1)

Metabolite Name

1,3-dipyridin-3-ylpropane-1,3-dione (1)
PE (18:0/18:1) (1)
PC (16:0/17:1) (1)
13,14-Dihydro prostaglandin E1 (1)
3'-O-Methylcytidine (1)
D-3-Phenyllactic acid (1)
Glycocholic acid hydrate (1)
O1-(4-chlorobenzoyl)-4-nitrobenzene-1-carbohydroximamide (1)
Orsellinic acid ethyl ester (1)
PA (16:0/18:2) (1)
PC (15:0/18:0) (1)
Cis-2-Decenoic acid (1)
19(R)-Hydroxy prostaglandin F1alpha (1)
PC (20:0/20:4) (1)
PE (17:0/18:1) (1)
5alpha-Dihydrotestosterone glucuronide (1)
5alpha-Dihydrotestosterone (1)
PC (18:1e/20:4) (1)
Epicatechin-3-O-gallate (1)
SM (d14:0/22:0) (1)
Sorbitan monopalmitate (1)
Vitamin B2 (riboflavin) (1)
PC (15:0/20:4) (1)
PE (16:0/18:1) (1)
5-nitro-2-{[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]thio}pyridine (1)
PC (16:1/20:4) (1)
Prostaglandin F3alpha (1)
Delta17-6-keto prostaglandin F1alpha (1)
5-amino-1-phenyl-1H-pyrazole-4-carbonitrile (1)
2-Hydroxyisocaproic Acid (1)

First Public Date

2014 (62)
2023 (44)
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2022 (40)
2024 (37)
2021 (35)
2015 (34)
2016 (32)
2019 (31)
2026 (30)
2018 (30)
2020 (27)
2017 (21)
2013 (11)

Study type

Transcription profiling by array (184)
RNA-seq of coding RNA (57)
ChIP-seq (35)
RNA-seq of coding RNA from single cells (9)
Methylation profiling by high throughput sequencing (7)
Comparative genomic hybridization by array (6)
Genotyping by array (4)
RNA-seq of non coding RNA (4)
Transcription profiling by RT-PCR (3)
Animal - One-color microarray (2)
ChIP-chip by tiling array (2)
Plant - High-throughput sequencing (2)
RNA-seq of total RNA (2)
Transcription profiling by SAGE (1)
Animal - High-throughput sequencing (1)
DNA-seq (1)
Methylation profiling by array (1)

Release Date

2015 (74)
2016 (61)
2013 (52)
2014 (51)
2019 (40)
2012 (40)
2022 (37)
2023 (34)
2021 (33)
2020 (32)
2018 (30)
2011 (30)
2017 (25)
2010 (24)
2025 (21)
2024 (18)
2008 (16)
2009 (13)
2026 (6)
2007 (6)
2005 (5)
2006 (4)
2002 (1)
1998 (1)

Lab affiliation

Head Proteomics Group Leiden University Medical Center Center for Proteomics and Metabolomics (1)
Cambridge Stem Cell Institute, Cambridge, United Kingdom, CB2 0AW (1)
Ludwig Boltzmann Institute Cancer Research, Vienna, Austria (1)
Shanghai Jiao Tong University Ming Yu Lab (1)
School of Basic Medical Sciences, Chongqing Medical University, Chongging, China (1)
Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria. (1)
Chemistry Department, The Scripps Research Institute, La Jolla, California, USA (1)
Lady Davis Institue for Medical Research, McGill University, Canada Department of Medicine, McGill University, Canada (1)
School of Basic Medical Sciences, Chongqing Medical Universityqing Medical Universityic Medical Sciences, Chongqing Medical University (1)
School of Basic Medical Sciences, Chongqing Medical University (1)
Proteomic Hematology, Division of Molecular Hematology, Lund Stem Cell Center, Lund University (1)
CSIR IICB (1)
Goethe-Universität Frankfurt, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, Frankfurt am Main, GERMANY (1)
Professor for Stem Cell Aging Faculty of Medicine Friedrich-Schiller-University Jena Erlanger Allee, 07747 Jena; Germany (1)
1Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands (1)
Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, School of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. (1)
University of Cambridge (1)
Department of Radiological Medicine, School of Basic Medical Sciences, Chongqing Medical University (1)
The University of Melbourne (1)

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13C mass isotopomer analysis (LCMS flux studies) MLL-AF9 (part III)

Not available

ORGANISM(S): Mus musculus

ST000170 | MetabolomicsWorkbench

13C mass isotopomer analysis (LCMS flux studies) MLL-AF9 (part II)

Not available

ORGANISM(S): Mus musculus

ST000157 | MetabolomicsWorkbench

13C mass isotopomer analysis (LCMS flux studies) MLL-AF9 (part I)

Not available

ORGANISM(S): Mus musculus

ST000308 | MetabolomicsWorkbench

AF9 Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here we show that the evolu...

ORGANISM(S): Homo sapiens

2014-12-11 | E-GEOD-60366 | biostudies-arrayexpress

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes

The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes downstream of MLL-AF9 (alias MLL-MLLT3) which could assist to develop new targeted therapi...

ORGANISM(S): Homo sapiens

2014-02-13 | E-GEOD-36592 | biostudies-arrayexpress

Aberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (ChIP-Seq)

We studied the chromatin modification patterns induced by the presence of the MLL-AF9 fusion protein in a model of human hematopoietic stem/progenitor cells (HSPC) transduced with retrovirus expressing MLL-AF9cDNA (HSPC-MA9). Comparative ChIP-seq analysis between HSPC-MA9 and control HSPC, revealed ...

ORGANISM(S): Homo sapiens

2015-03-01 | E-GEOD-54344 | biostudies-arrayexpress

Integrative epigenomic analysis in MLL-AF9 acute myeloid leukemia (AML) and B-acute lymphoblastic leukemia (B-ALL)

Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib...

ORGANISM(S): Homo sapiens

2017-05-02 | E-GEOD-70755 | biostudies-arrayexpress

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

This SuperSeries is composed of the following subset Series: GSE36346: The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (ChIP-Seq data) GSE36347: The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (expression dat...

ORGANISM(S): Mus musculus

2012-03-28 | E-GEOD-36348 | biostudies-arrayexpress

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (ChIP-Seq data)

Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing di...

ORGANISM(S): Mus musculus

2012-03-28 | E-GEOD-36346 | biostudies-arrayexpress

Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cells

MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone mar...

ORGANISM(S): Mus musculus

2011-09-12 | E-GEOD-25911 | biostudies-arrayexpress

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