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ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
TranscriptomicsTCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase
To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h. Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose N...
ORGANISM(S): Homo sapiens 
2013-02-11 | E-GEOD-42922 | biostudies-arrayexpress
ProteomicsAffinity capture enrichment versus Affinity depletion: A comparison of strategies for increasing coverage of low abundant human plasma proteins
present study, we evaluated four small molecule affinity-based probes based on agarose-immobilized benzamidine (ABA), O-Phospho-L-Tyrosine (pTYR), 8-Amino-hexyl-cAMP (cAMP), or 8-Amino-hexyl-ATP (ATP) for their ability to remove high-abundant proteins such as serum albumin from plasma samples thereb...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD020727 | Pride
Affinity enrichment Depletion Human plasma 
ProteomicsIdentification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using Tandem Affinity Purification and Mass Spectrometry
According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-19 | MSV000091093 | MassIVE
GenomicsIdentification of high-affinity microRNA targets
Identification of high-affinity microRNA targets
PRJEB18708 | ENA
TranscriptomicsChromosomal High Affinity Binding Sites for the Drosophila Dosage Compensation Complex.
We identified 131 high affinity sites of the Drosophila DCC combining residual ChIP-chip profiles after differential crosslinking and RNAi-mediated knockdown of spreading factors Keywords: ChIP-chip MSL1 and MSL2 ChIP under various conditions including differential crosslinking and RNAi against MOF...
ORGANISM(S): Drosophila melanogaster 
2008-12-13 | E-GEOD-12292 | biostudies-arrayexpress
GenomicsRegulated somatic hypermutation enhances antibody affinity maturation
Regulated somatic hypermutation enhances antibody affinity maturation
PRJNA1211152 | ENA
GenomicsIRF4 Haploinsufficiency Impairs Affinity Maturation
IRF4 Haploinsufficiency Impairs Affinity Maturation
PRJNA767888 | ENA
GenomicsRNAs associated with affinity captured LINE-1 ribonucleoproteins
RNAs associated with affinity captured LINE-1 ribonucleoproteins
PRJNA423015 | ENA
ProteomicsLight-controlled affinity purification of protein complexes
Methods to affinity purify proteins are widely used in protein research. One important application is to identify interacting proteins of an affinity-purified protein of interest (POI) by mass spectrometry. Here, we developed an optogenetics-derived and light-controlled affinity purification method ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-18 | PXD012156 | Pride
Affinity purification Mass spectrometry Optogenetics Protein-protein interaction Phytochrome Zap70 
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