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ProteomicsIdentification of the intermolecular disulfide bonds between NPGPx and ZAP70
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017034 | Pride
Zap70 Npgpx Disulfide bond 
TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia patients expressing high or low levels of ZAP70 mRNA
Comparison of Chronic Lymphocytic Leukemia patients expressing high or low levels of ZAP70 mRNA: prognostic factors and interaction with the microenvironment. Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia (CLL), but mechanisms by which it...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-12734 | biostudies-arrayexpress
ProteomicsLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell antigen receptor (TCR) signaling depends upon the kinases Lck and Zap70. Lck phosphorylates the TCR, facilitating Zap70 recruitment to the stimulated TCR. Lck also phosphorylates Zap70, relieving its auto-inhibition and activating its catalytic domain. Zap70 then phosphorylates the critical a...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008258 | Pride
Jurkat t cell line Lat Tcr signaling Mice Lck Zap70 
GenomicsIncreased Th17 Cell Pathogenicity in Periodontitis: Association of Zap70
Increased Th17 Cell Pathogenicity in Periodontitis: Association of Zap70
PRJNA1424879 | ENA
GenomicsDevelopmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
PRJNA625737 | ENA
ProteomicsAnalysis of the interactomes of ZAP70, CD247 and SLP76 upon stimulation of murine CD8+ T cells with ligands of different affinity to the TCR
T cells have the remarkable ability to sense and discriminate between a wide range of antigenic peptides bound to major histocompatibility complex molecules (pMHC). Here, we use interactomics to monitor in a time dependent manner the early molecular events taking place upon stimulation of murine CD8...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-05 | PXD029974 | Pride
Ap-ms Tcr Slp76 Cd3z Primary cd8+ t cell Ot-i mouse Zap70 Interactome Cd247 Ost tag 
UnknownLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
Not available
S-EPMC6202249 | biostudies-literature
GenomicsGene expression analysis of Eu-TCL1 CLL cells with Zap70 expression
Gene expression analysis of Eu-TCL1 CLL cells with Zap70 expression
PRJNA670854 | ENA
TranscriptomicsIncreased Th17 Cell Pathogenicity in Periodontitis: Association of Zap70
The progression of periodontitis is closely associated with Th17 cells, yet the functional differences of Th17 cells under periodontitis conditions remain poorly understood. Therefore, we established an experimental periodontitis model using IL-17GFP/+ transgenic mice, isolated Th17 cells via flow c...
ORGANISM(S): Mus musculus 
2026-02-20 | GSE319621 | GEO
ProteomicsWithaferin A inhibits LFA-1-stimulated ZAP70 activity and T-cell motility
a steroidal lactone withaferin A (WFA) can inhibit T-cell motility, which is crucial for adaptive immune responses as well as autoimmune reactions. Tandem mass spectrometry identified WFA-interactome in human T-cells that were stimulated to migrate via cross-linking of the lymphocyte function-associ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026508 | Pride
T-lymphocytes Inflammation Migration Withaferin a Kinome 
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