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ProteomicsIdentification of NPGPx-interacting proteins in activated T cells
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017046 | Pride
T cell activation Zap70 Npgpx 
ProteomicsIdentification of the intermolecular disulfide bonds between NPGPx and ZAP70
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017034 | Pride
Zap70 Npgpx Disulfide bond 
UnknownDeficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Not available
S-EPMC3944459 | biostudies-literature
UnknownNPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress.
Not available
S-EPMC4627054 | biostudies-literature
UnknownA cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress.
Not available
S-EPMC3561993 | biostudies-literature
UnknownDriving adult tissue repair via re-engagement of a pathway required for fetal healing.
Not available
S-EPMC9931555 | biostudies-literature
TranscriptomicsMicroarray Analysis of chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma
OBJECTIVE: To investigate the differentially expressed genes and miRNAs related to the chemosensitivity of hypopharyngeal squamous cell carcinoma （HSCC）by microarrays and miRNA arrays. METHODS: 1. A total number of 21 patients who underwent induction chemotherapy for primary hypopharyngeal squ...
ORGANISM(S): Homo sapiens 
2016-08-16 | E-GEOD-85608 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling of Hippocampal CA1 After Early Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies for Epilepsy
Injury of the CA1 subregion induced by a single injection of kainic acid (1M-CM-^WKA) is attenuated when juvenile animals (P20) have a history of two sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early life conditioning...
ORGANISM(S): Rattus norvegicus 
2013-02-14 | E-GEOD-44031 | biostudies-arrayexpress
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