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TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD8+ T cells from BM3.3 transgenic mice during responses to TCR ligands of different avidity
To identify the molecular bases for divergence in differentiation programs of naïve CD8 T cells, we monitored gene expression profile of CD8+ T cells from BM3.3 transgenic mice during responses to TCR ligands of different avidity (full response with antigen presenting cells from C57BL/6 mice , parti...
ORGANISM(S): Mus musculus 
2004-07-07 | E-MEXP-16 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD4+CD8+ thymocytes following engagement of TCR with anti-Valpha or Vbeta antibodies
Comparison of gene expression changes in CD4+CD8+ thymocytes following engagement of TCR with anti-Valpha or Vbeta antibodies
ORGANISM(S): Mus musculus 
2007-09-28 | E-GEOD-1448 | biostudies-arrayexpress
ProteomicsA TCR blocking HLA-A*11:01-specific human monoclonal antibody
Cross-linking mass spectrometry and Targeted cross-linking mass spectrometry for a TCR blocking human monoclonal antibody targeting HLA-A*11:01
ORGANISM(S): Homo Sapiens (human) 
2025-06-02 | PXD053836 | JPOST Repository
ProteomicsGlobal phosphoproteomics for CRISPR/Cas9 mediated PTPN22 Ser325 mutagenesis on Jurkat cells
LQF of 3x FLAG PTPN22 WT Jurkat cells compared to S325A and S325E KI mutant Jurkat cells. WT or KI lines were stimulated with or without TCR engagement for 5 min.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093718 | MassIVE
TranscriptomicsTCR Rep-Seq of COVID-19 affected individuals
5'RACE-based TCR repertoire sequencing from peripheral blood
ORGANISM(S): Homo sapiens 
2024-09-26 | E-MTAB-13593 | biostudies-arrayexpress
TranscriptomicsGene expression of TCR-alpha/beta CD4- CD8- human T cells
The origin and function of human double negative (DN) TCR-alpha/beta T cells is unknown. They are thought to contribute to the pathogenesis of systemic lupus erythematosus because they expand and accumulate in inflamed organs. Here we provide evidence that human TCR-alpha/beta CD4- CD8- DN T cells...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-16130 | biostudies-arrayexpress
ProteomicsImmunoprecipitated PTPN22 Phosphoproteomics from Jurkat Cells
3x FLAG tagged PTPN22 were immunoprecipitated from Jurkat cells stimulated by TCR for 5min, and the proteins were eluted by FLAG peptides. This study aims to explore the phosphorylation sites on PTPN22 phosphatase, identifying two phosphorylation sites Ser325 and Ser449.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093717 | MassIVE
TranscriptomicsSingle cell TCR-seq profiling of T cells isolated from LNs of MC38 tumor-bearing mice
We investigate the single-cell landscape of the inflammatory mouse tumor model MC38, a C57BL/6 tumor cell line derived from colon adenocarcinoma. MC38 (diluted in HBSS and matrigel) was inoculated in the right unilateral flank (in the border of positions B2 and B3) of C57BL/6 mice (ref Study 16-3384...
ORGANISM(S): Mus musculus 
2022-08-16 | E-MTAB-9734 | biostudies-arrayexpress
TranscriptomicsExpression data from P14 TCR cytotoxic T cells overexpressing HDAC7 phosphorylation deficient mutant
The present study reports an unbiased analysis of the cytotoxic T cell serine-threonine phosphoproteome using high resolution mass spectrometry. Approximately 2,000 phosphorylations were identified in CTLs of which approximately 450 were controlled by TCR signaling. A significantly overrepresented g...
ORGANISM(S): Mus musculus 
2011-03-13 | E-GEOD-27092 | biostudies-arrayexpress
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