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ProteomicsLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell antigen receptor (TCR) signaling depends upon the kinases Lck and Zap70. Lck phosphorylates the TCR, facilitating Zap70 recruitment to the stimulated TCR. Lck also phosphorylates Zap70, relieving its auto-inhibition and activating its catalytic domain. Zap70 then phosphorylates the critical a...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008258 | Pride
Jurkat t cell line Lat Tcr signaling Mice Lck Zap70 
GenomicsKlebsiella pneumoniae strain:LAT-03
Klebsiella pneumoniae strain:LAT-03 Genome sequencing
PRJNA1510337 | ENA
TranscriptomicsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
The aim of the dataset was to study on a genome-wide level the impact of Lat deficiency on gene expression in resting and activated CD4+ T cells Lat+ and Lat? CD4+ T cells were isolated from lymph nodes and spleen of Latfl-dtr Tmat-Cre mice using a Dynabeads untouched mouse CD4 cells kit (Life Techn...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-49507 | biostudies-arrayexpress
GenomicsHomo sapiens isolate:J-Lat 10.6
RNA-seq analysis of TFD-treated J-Lat 10.6 cells
PRJNA1304135 | ENA
ProteomicsRBM39 organizes an m⁶A-dependent silencing complex to degrade Tat mRNA and maintain HIV-1 latency
Given the pivotal role of Tat in HIV-1 latency, we performed RNA pull-down assays in latently HIV-1-infected J-Lat 10.6 cells using biotinylated RNA probes (including a control RNA probe and a Tat-specific RNA probe) . Cell lysates were incubated with streptavidin agarose resin pre-bound to Tat RNA ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD064834 | Pride
Lc/ms Tat Rip J-lat 10.6 
GenomicsHarmine treatment of PMA-treated J-Lat 5A8 cells
Harmine treatment of PMA-treated J-Lat 5A8 cells
PRJNA561499 | ENA
ProteomicsDNA-PKcs governs LAT-dependent signaling in CD4+ and CD8+ T cells
Quantitative data-independent acquisition (DIA) analysis of LAT IP from human Jurkat T cells
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD060934 | Pride
Human T cells 
ProteomicsAPEX2-based quantitative proteomic study of LAT and CD3z in Jurkat T cells
TCR binding to its ligands induces a cascade of signaling starting by the phosphorylation of immunoreceptor tyrosine-based activation motif (ITAMs) present in the TCR-associated CD3 complex. This is followed by the phosphorylation of proteins including the adaptor LAT, which once phosphorylated inte...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD060106 | Pride
Tcr signaling T lymphocyte Proximity ligation assay 
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
UnknownLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
Not available
S-EPMC6202249 | biostudies-literature
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