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ProteomicsSynaptotagmin 13 drives pancreatic endocrine cell egression and islet morphogenesis: Affinity purification
Identification of protein complexes for the synaptotagmin 13 protein from MDCK cells by Strep affinity purificaiton and LFQ mass spectrometry. Epithelial cell egression is important for organ development and cell differentiation, but also drives cancer metastasis. The tightly connected pancreatic ep...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2023-12-28 | PXD026698 | Pride
Affinity purification Protein complexes Synaptotagmin 13 
ProteomicsSWATH analysis of 1433B_HUMAN affinity purifications from HEK293 cells after time course treatment with IGF1
Protein complexes and protein interaction networks are essential mediators of most biological functions. Complexes supporting transient functions such as signal transduction processes are frequently subject to dynamic remodeling. Currently, the majority of studies into the composition of protein com...
ORGANISM(S): Homo sapiens (Human) 
2013-09-25 | PXD000343 | Pride
Ap-ms Ap-swath Quantitative interaction proteomics Affinity purificaiton 
TranscriptomicsExpression data from Drd1a and Drd2 expressing neurons in striatum and cortex, at 6 weeks and 2 years of age
We performed a study of gene expression changes that occur during mouse aging in the striatum and cortex in specific neuronal populations. Using translating ribosome afifnity purificaiton, we captured cell type-specific mRNAs from Drd1a-expressing cortical neurons, Drd1a-expressing striatal neurons...
ORGANISM(S): Mus musculus 
2014-12-13 | E-GEOD-64140 | biostudies-arrayexpress
ProteomicsAnalysis of the substrate specificities and reaction kinetics of the yeast oligosaccharyltransferase isoforms
Oligosaccharyltransferase (OST) catalyzes the central step in N-linked protein glycosylation, the transfer of a pre-assembled oligosaccharide from its lipid carrier onto asparagine residues of secretory proteins. The prototypic hetero-octameric OST complex from the yeast Saccharomyces cerevisiae exi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-05-19 | PXD024590 | Pride
Site-occupancy Yeast oligosaccharyltransferase Substract specificity 
TranscriptomicsThe ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter proximal nucleosomes [array]
The evolutionarily conserved ATP-dependent chromatin remodeling enzyme Fun30 has recently been shown to play important roles in heterochromatin silencing and DNA repair. However, how Fun30 remodels nucleosomes is not clear. Here we report a nucleosome sliding activity of Fun30 and its role in transc...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-08 | E-GEOD-48570 | biostudies-arrayexpress
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