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TranscriptomicsTranscription profiling of XX and XY sorted mouse somatic support cells and XX and XY mouse whole gonads to identify potential new mammalian gonadal sex determining genes.
Gonadal sex determining (GSD) genes that initiate fetal ovarian and testicular development and differentiation are expressed in the cells of the urogenital ridge that differentiate as somatic support cells (SSCs), i.e., granulosa cells of the ovary and Sertoli cells of the testis. To identify potent...
ORGANISM(S): Mus musculus 
2007-11-30 | E-GEOD-4928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of immature germinal vesicle stage oocytes with mature metaphase II oocytes to identify and characterize the changed and stable transcripts during mouse oocyte maturation.
There is massive destruction of transcripts during maturation of mouse oocytes. The objective of this project was to identify and characterize the transcripts that are degraded versus those that are stable during the transcriptionally silent germinal vesicle (GV)-stage to metaphase II (MII)-stage t...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5668 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cumulus cells from Bmp15-/- and Bmp15-/-Gdf9+/--DM animals
Mouse oocytes control cumulus cell metabolic processes that are deficient in the oocytes themselves and this delegation is necessary for oocyte development. Oocyte-derived bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) appear to be key regulators of follicular devel...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7225 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adipose tissue from lipodystrophic mice
This SuperSeries is composed of the following subset Series:; GSE9130: aP2-nSREBP1c_white_Adipose_Tissue_expression_differentials; GSE9131: Pparg_white_Adipose_Tissue_expression_differentials Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adipose tissue from Pparg animals
Identifying gene expression changes in adipose tissue of lipodystrophic Pparg targeted mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old Pparg males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ?¢ arrays, one mouse p...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9131 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adipose tissue of lipodystrophic aP2-nSREBP1c trangenic animals
Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old aP2-nSREBP1c transgenic males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ„¢ arrays,...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9130 | biostudies-arrayexpress
Transcriptomics8-chip high-resolution aCGH experiment NA15510 vs. NA18505
We introduce high-throughput and massive paired-end mapping (PEM), a large-scale genome sequencing method to identify SVs 3 kb or larger that combines the rescue and capture of paired-ends of 3 kb fragments, massive 454 Sequencing, and a computational approach to map DNA reads onto a reference genom...
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-9002 | biostudies-arrayexpress
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