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ProteomicsRecombinant Ag85B Glycoproteomics
A bacterial antigen (Ag85B) was recombinantly expressed in Expi293 cells in which non-native N-glycosylation occured. We used glycoproteomics to characterize site-specific glycosylation across the surface of Ag85B as informed by glycomics data.
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD077483 | Pride
Ag85b Glycoproteomics Mtb 
GenomicsBCG overexpressing Ag85B reprograms host immune response through coordinated transcriptional networks
BCG overexpressing Ag85B reprograms host immune response through coordinated transcriptional networks
PRJNA1504242 | ENA
TranscriptomicsBCG overexpressing Ag85B reprograms host immune response through coordinated transcriptional networks
Antigen 85B (Ag85B), an immunodominant protein secreted by Mycobacterium tuberculosis (Mtb), induces robust T-cell-mediated immunity in host cells. Previous studies have demonstrated that recombinant BCG strains overexpressing Ag85B (BCG85B) confer significant protection against tuberculosis in mous...
ORGANISM(S): Mus musculus 
2026-09-02 | GSE341826 | GEO
GenomicsFull transcriptome and proteome analysis of the mechanism of tuberculosis Ag85B-Fc2a in alleviating allergic asthma in mice
Full transcriptome and proteome analysis of the mechanism of tuberculosis Ag85B-Fc2a in alleviating allergic asthma in mice
PRJNA1120385 | ENA
TranscriptomicsFull transcriptome and proteome analysis of the mechanism of tuberculosis Ag85B-Fc2a in alleviating allergic asthma in mice
In the early stage, an OVA-induced mouse allergic asthma model was constructed and treated with Ag85B-Fc2a fusion protein, which proved that Ag85B-Fc2a fusion protein could reduce the infiltration of inflammatory cells in the lungs and had a therapeutic effect on asthma。In order to further explore t...
ORGANISM(S): Mus musculus 
2025-06-05 | GSE269136 | GEO
UnknownOptimization of codon usage enhances the immunogenicity of a DNA vaccine encoding mycobacterial antigen Ag85B.
Not available
S-EPMC1231050 | biostudies-literature
UnknownAssessment of the genetic diversity of Mycobacterium tuberculosis esxA, esxH, and fbpB genes among clinical isolates and its implication for the future immunization by new tuberculosis subunit vaccines Ag85B-ESAT-6 and Ag85B-TB10.4.
Not available
S-EPMC2896655 | biostudies-literature
UnknownDNA vaccine using Mycobacterium bovis Ag85B antigen induces partial protection against experimental infection in BALB/c mice.
Not available
S-EPMC1539111 | biostudies-literature
UnknownGene-based neonatal immune priming potentiates a mucosal adenoviral vaccine encoding mycobacterial Ag85B.
Not available
S-EPMC5131305 | biostudies-literature
UnknownFusion of Dendritic Cells Activating Rv2299c Protein Enhances the Protective Immunity of Ag85B-ESAT6 Vaccine Candidate against Tuberculosis.
Not available
S-EPMC7690420 | biostudies-literature
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