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ProteomicsEvaluating protein crosslinking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monomers that seed toxic aggregates. Considerable resear...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-17 | PXD047030 | Pride
Cross-linking Pharmacological chaperone Amyotrophic lateral sclerosis (als) Stabilization Sod1 
ProteomicsApteronotus leptorhynchus central nervous system proteome
The brown ghost knifefish (Apteronotus leptorhynchus) is a weakly electric teleost fish of particular interest as a model organism for a variety of research areas in neuroscience, including neurophysiology, neuroethology, and neurobiology. This versatile model system has been more recently used in t...
ORGANISM(S): Apteronotus leptorhynchus 
2015-07-16 | PXD001285 | Pride
Apteronotus leptorhynchus Brain Spinal cord 
ModelsMorris2008 - Fitting protein aggregation data via F-W 2-step mechanism
Morris2008 - Fitting protein aggregation data via F-W 2-step mechanism This model is described in the article: Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic ...
2024-09-02 | BIOMD0000000567 | BioModels
ProteomicsMass Spectrometry Methods and Mathematical PK/PD Model for Decision Tree-Guided Covalent Drug Development
Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect [i.e., uncoupling of pharmacokinetics (PK) and pharmacodynamics (PD...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-23 | PXD046903 | Pride
Covalent drug discovery Als Intact protein mass spectrometry Pk/pd 
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