Bulk RNA seq of single gastruloids at 48h post-aggregation and 96h post-aggregation. Two different conditions were compared: control vs glycolysis inhibited (6mM 2-deoxy-D-glucosebetween, 24h-48h post aggregation). Aim of the study was to determine short-term effects of glycolysis inhibition on tran...
The discovery that sponges (Porifera) can fully regenerate from aggregates of dissociated cells launched them as one of the earliest experimental models to study the evolution of cell adhesion and allorecognition in animals. This process depends on an extracellular glycoprotein complex called the Ag...
Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, characterized by poor clinical outcomes, primarily driven by high rate of locoregional recurrence and metastasis. Extensive heterogeneity among the tumor cells as well as modulation of a highly immunosuppressive tumor microen...
Protein aggregates occur in all living cells due to misfolding of proteins. In bacteria, protein aggregation is associated with cellular inactivity, which is related to dormancy and tolerance to stressful conditions, including the exposure to antibiotics. In Escherichia coli, the membrane toxin TisB...
Proctor2012 - Amyloid-beta aggregation
This model supports the current thinking that levels of dimers are important in initiating the aggregation process.
This model is described in the article:
Aggregation, impaired degrad...
This model is from the article:
Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis
Proctor CJ, Lorimer IAJ
PLoS ONE2011; 6(7): e22038.
doi:10.1371/journal.pone.0022038,
Abstract:
Neurodegeneration is a...
The formation of protein aggregates is a hallmark of neurodegenerative diseases. Observations on patient material and model systems demonstrated links between aggregate formation and declining mitochondrial functionality, but the causalities remained unclear. We used yeast as model system to analyze...
Protein aggregation in the outermost layers of the cornea, leading to cloudy vision and in severe cases blindness, is linked to mutations in the extracellular matrix protein, transforming growth factor-β-induced protein (TGFBIp). Among the most frequent disease-causing mutations are R124H and R555W,...
