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ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo Sapiens 
2021-01-23 | PXD011261 | panorama
UnknownProteome-scale understanding of relationship between homo-repeat enrichments and protein aggregation properties.
Not available
S-EPMC6219797 | biostudies-literature
TranscriptomicsTranscription profiling of generic impact of protein aggregation (aggregation of proteins not associated with neurodegenerative disease) on gene expression in human cultured cells
In this study the generic impact of protein aggregation (aggregation of proteins not associated with neurodegenerative disease) on gene expression in cultured cells was investigated by DNA microarray technology. The survey of gene expression showed that the Hsp40, Hsp70 and Hsp105 genes, all of whic...
ORGANISM(S): Homo sapiens 
2005-07-20 | E-MEXP-389 | biostudies-arrayexpress
TranscriptomicsCardiac Gene Expression Profiling in CryAB R120G Transgenic Mice
Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small HSP ?B-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of...
ORGANISM(S): Mus musculus 
2008-12-12 | E-GEOD-9924 | biostudies-arrayexpress
TranscriptomicsSmall molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UP...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-84636 | biostudies-arrayexpress
ProteomicsAggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells
Proteostasis is maintained by optimum expression, folding, transport, and clearance of proteins. Deregulation of any of these processes triggers protein aggregation and is implicated in many age-related pathologies. Here, using quantitative proteomics and microscopy we show that aggregation of many ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-28 | PXD012204 | Pride
Proteomics Proteostasis Mitochondrial respiratory chain complex Low complexity region Protein turnover Mitochondria Protein misfolding Protein aggregation 
Unknownsw ApoMb Amyloid Aggregation under Nondenaturing Conditions: The Role of Native Structure Stability.
Not available
S-EPMC5611671 | biostudies-literature
UnknownA peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides.
Not available
S-EPMC6032367 | biostudies-literature
GenomicsRNA-DNA hybrids formed in the absence of Senataxin drive non-coding RNA expression and protein aggregation in the nucleolus
RNA-DNA hybrids formed in the absence of Senataxin drive non-coding RNA expression and protein aggregation in the nucleolus
PRJNA1004589 | ENA
TranscriptomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during ageing and in protein aggregation-associated diseases. This RNA-seq study in Saccharomyces cerevisiae investigated the role of Tsa1, which is a member of the highly ...
ORGANISM(S): Saccharomyces cerevisiae 
2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress
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