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ProteomicsProteome solubility changes under different proteostasis stresses
The accumulation of aberrant protein aggregates in neurodegenerative diseases is associated with a widespread failure of the protein homeostasis system. To investigate whether there is a subproteome that consistently aggregates under stress and define the broader determinants for protein aggregation...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD015573 | Pride
Metabolism Huntington’s disease Protein homeostasis Protein aggregation Er-mediated folding inhibition Stress granule formation Aggregomics Nuclear pore Hsp70 Protein misfolding Molecular chaperones Oxidative stress Hsp90 Proteasome 
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