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TranscriptomicsHsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis with no increased bleeding risk
Atrial fibrillation (AF) is a major risk factor for cardioembolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern particularly when antiplatelet treatment is simultaneously administer...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-66724 | biostudies-arrayexpress
TranscriptomicsWidespread regulation of translation by elongation pausing in heat shock
RNA-seq and ribosome footprinting libraries of mouse 3T3 and human 293T cellsrelated to Shalgi et al. 2013 36bases paired-end RNA-seq, and ribosome footprinting libraries for: 3T3 cells - Control, 8 hours of mild heat shock (42) and 2 hours of severe heat shock (44) - in replicates, as well as 3T3 ...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-32060 | biostudies-arrayexpress
ProteomicsHsp70 ATP-dependent dimerization and Chaperone/Co-chaperone Interactions
Eukaryotic protein homeostasis (proteostasis) is largely dependent on the action of highly conserved Hsp70 molecular chaperones. Recent evidence indicates that apart from conserved molecular allostery, Hsp70 proteins retained and adapted throughout the evolution the ability to assemble as functional...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010069 | Pride
Tomm34 Hsp70 Co-chaperone Dimer Chip 
TranscriptomicsHsp70 and a Novel Axis of Type 1 Interferon-Dependent Antiviral Immunity in the Measles Virus-Infected Brain
The major inducible 70 kDa heat shock protein (hsp70) is host protective in a mouse model of measles virus (MeV) brain infection. Transgenic constitutive expression of hsp70 in neurons, the primary target of MeV infection, abrogates neurovirulence in neonatal H-2d congenic C57BL/6 mice. A significan...
ORGANISM(S): Mus musculus 
2012-11-14 | E-GEOD-42264 | biostudies-arrayexpress
TranscriptomicsRole of HSP70 in response to (thermo)radiotherapy: analysis of gene expression in canine osteosarcoma cells by RNA-seq
The aim of the study was to investigate which genes are up- and down-regulated in response to hyperthermia and combined thermoradiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line. Canine osteosarcoma cell line Abrams was transfected with negative control siRNA or siRNA target...
ORGANISM(S): Canis lupus familiaris 
2020-07-30 | E-MTAB-8652 | biostudies-arrayexpress
ModelsDudziuk2019 - Biologically sound formal model of Hsp70 heat induction
This is a mathematical model of Hsp70 induction. To model heat shock effects, the model incorporates temperature dependencies in transcirption to Hsp70 mRNA and in dissociation of transcriptional complexes, in addition to a formal expression relating temperature to protein denaturation.
2024-09-02 | BIOMD0000000843 | BioModels
ProteomicsMitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer
TMT-MS of whole cell lysate collected from 22Rv1 castration-resistant prostate cancer cells treated with 5 µM JG-98 for 4 hours.
ORGANISM(S): Homo Sapiens (human) 
2023-04-25 | PXD038684 | JPOST Repository
TranscriptomicsTranscription profiling of AtHsp70-14 and AtHsp70-15 deficient Arabidopsis thaliana plants
AtHsp70-14 and -15 (At1g79930 and At1g79920) are two closely related isoforms of the Hsp110/SSE subfamily of the HSP70 chaperones in Arabidopsis thaliana. By analysing T-DNA insertion and amiRNA-AtHsp70-14/15 lines, we could demonstrate an essential function of AtHsp70-15 for plant growth. AtHsp70-1...
ORGANISM(S): Arabidopsis thaliana 
2011-03-28 | E-MEXP-3082 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse substantia nigra from wild type mice and mice overexpressing human aSYN, human hsp70 and aSYN / hsp70 to investigate synucleiopathies
Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) are the two most common examples of synucleinopathies, i.e. human disorders that display intracellular deposition of the Alpha-synuclein (aSYN) protein. The two forms of aSYN deposits, intracellular Lewy bodies and Lewy neurites, are in ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4758 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse preshocked hsp70(-/-) and (+/+) cells to assess thermotolerance
From preliminary experiments, HSP70 deficient MEF cells display moderate thermotolerance to a severe heatshock of 45.5 degrees after a mild preshock at 43 degrees, even in the absence of hsp70 protein. We would like to determine which genes in these cells are being activated to account for this ther...
ORGANISM(S): Mus musculus 
2009-04-17 | E-GEOD-11120 | biostudies-arrayexpress
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