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ProteomicsLamin A dimer and tetramer cross-links help explain disease mutations and polymer plasticity
Lamins are intermediate filament proteins responsible for nuclear mechanical integrity. Though linked to multiple heritable diseases, lamin structure and that of other intermediate filaments remains elusive. We employed cross-linking mass spectrometry to gain structural insights into lamin A dimer a...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2019-07-12 | PXD008337 | Pride
Silac Cross-link mass spectrometry Em Lamin a 
ProteomicsDetection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo
The immediate early gene product activity-regulated cytoskeleton-associate protein (Arc or Arg3.1) is a major regulator long-term synaptic plasticity with critical roles in postnatal cortical development and memory formation. However, the molecular basis of Arc function is not defined. Arc is a hub ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD039612 | Pride
Arc oligomer Dimer Rat brain 
GenomicsCharacterization of DENV E-dimer-Binding Memory B cells and Antibodies
Characterization of DENV E-dimer-Binding Memory B cells and Antibodies
PRJNA1393072 | ENA
ProteomicsLaboratory evolution in Novosphingobium aromaticivorans enables rapid catabolism of a model lignin-derived aromatic dimer
Lignin contains a variety of interunit linkages, which leads to a range of potential decomposition products that can be used as carbon and energy sources by microbes. B-O-4 linkages are the most common in native lignin and associated catabolic pathways have been well characterized. However, the fate...
ORGANISM(S): Novosphingobium Aromaticivorans (ncbitaxon:48935) 
2024-08-29 | MSV000095729 | MassIVE
ProteomicsA novel C-terminal DxRSDxE motif in ceramide synthases involved in dimer formation
Ceramide is synthesized via the ceramide synthases (CerSs), six of which have been identified in mammalian cells, with each using a unique subset of acyl-CoAs for ceramide synthesis. The CerSs are part of a larger gene family, the Tram-Lag-CLN8 (TLC) domain family. We now identify a unique, C-termin...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD029496 | Pride
Motif Ceramide synthase Ceramide Dimer Sphingolipids 
ProteomicsIntegrative structure models of the α-Synuclein dimer conformations
α-Synuclein is an intrinsically disordered protein known for its contributions to functions in neurons but mostly in its contributions to the development of Parkinson's disease via formation of self-associated forms, fibrils and Lewy bodies. Among the multiple targets it interacts with and gains a f...
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD030299 | Pride
Α-synuclein Dimer Parkinson's Hetreo isotopic cl-ms 
GenomicsAromatic dimer dehydrogenases from Novosphingobium aromaticivorans reduce aromatic diketones
Aromatic dimer dehydrogenases from Novosphingobium aromaticivorans reduce aromatic diketones
PRJNA731907 | ENA
TranscriptomicsResponse of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer.
Objectives ELB-21 is a pyrrolo[2,1-c][1,4]benzodiazepine dimer with potent antistaphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory proteins and transcription elongation in a sequence-selective manner. Transcriptional and pro...
ORGANISM(S): Staphylococcus aureus 
2009-09-18 | E-BUGS-79 | biostudies-arrayexpress
ProteomicsEvaluating protein crosslinking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monomers that seed toxic aggregates. Considerable resear...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-17 | PXD047030 | Pride
Cross-linking Pharmacological chaperone Amyotrophic lateral sclerosis (als) Stabilization Sod1 
TranscriptomicsCharacterization of DENV E-dimer-Binding Memory B cells and Antibodies
We investigated sE-dimer-binding memory B-cell responses in a well-characterized cohort of patients with hospitalized dengue and their subclinical household contacts. Using sE-dimer-binding B-cell staining, single-cell RNA sequencing, and ex vivo single-B-cell cultures, we defined persistence, reper...
ORGANISM(S): Homo sapiens 
2026-08-05 | GSE314883 | GEO
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