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ProteomicsDisrupting metformin adaptation of hepatocellular carcinoma by targeting TOMM34/ATP5B axis
As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characteriz...
ORGANISM(S): Homo Sapiens 
PXD035365 |
UnknownThe interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
Not available
S-EPMC7335785 | biostudies-literature
UnknownExploiting Multi-Omics Profiling and Systems Biology to Investigate Functions of TOMM34.
Not available
S-EPMC9952762 | biostudies-literature
UnknownTOMM34 serves as a candidate therapeutic target associated with immune cell infiltration in colon cancer.
Not available
S-EPMC9948080 | biostudies-literature
UnknownDisrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis.
Not available
S-EPMC9728056 | biostudies-literature
UnknownNovel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities.
Not available
S-EPMC4858950 | biostudies-literature
UnknownRole of TOMM34 on NF-κB activation-related hyperinflammation in severely ill patients with COVID-19 and influenza.
Not available
S-EPMC11418153 | biostudies-literature
UnknownRT-qPCR analysis of the tumor antigens TOMM34 and RNF43 in samples extracted from paraffin-embedded specimens of colorectal cancer.
Not available
S-EPMC5530021 | biostudies-literature
ProteomicsHsp70 ATP-dependent dimerization and Chaperone/Co-chaperone Interactions
Eukaryotic protein homeostasis (proteostasis) is largely dependent on the action of highly conserved Hsp70 molecular chaperones. Recent evidence indicates that apart from conserved molecular allostery, Hsp70 proteins retained and adapted throughout the evolution the ability to assemble as functional...
ORGANISM(S): Homo sapiens (Human) 
2018-12-11 | PXD010069 | Pride
Tomm34 Hsp70 Co-chaperone Dimer Chip 
ClinicalHistocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Colorectal Cancer
The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 restricted epitope peptides RNF43, TOMM34, VEGFR1 and VEGFR2 emulsified with Montanide ISA 51 in combination with Tegafur/Uracil/Folinate chemotherapy.
2055342 | ecrin-mdr-crc
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