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ProteomicsRET Kinase Inhibition in Neuroendocrine Prostate Cancer, part 2
Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD012971 | Pride
Human Kinase Phosphoproteomics Prostate cancer Ret 
TranscriptomicsTMPRSS2-ERG fusion prostate cancer is a molecularly distinct estrogen-sensitive subclass of aggressive prostate cancer
Common epithelial cancers are believed to become more aggressive through the accumulation of multiple independent molecular events that lead to the deregulation of cell signaling. However, the discovery that the majority of prostate cancers harbor gene fusions of the 5'-untranslated region of androg...
ORGANISM(S): Homo sapiens 
2008-05-27 | E-GEOD-8402 | biostudies-arrayexpress
TranscriptomicsTop2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer
We perform RNA-seq on matched orthotopic murine primary and metastatic prostate cancer samples to identify differential gene expressions RNA-seq was performed on orthotopic murine primary and metastatic tumor samples using Illumina Hi-Seq 2000 platform
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-64771 | biostudies-arrayexpress
ProteomicsGlycoprotein Signatures for Aggressive Prostate Cancer via SWATH mass spectrometry
The identification of biomarkers indicating the level of aggressiveness of prostate cancer (PCa) addresses an urgent clinical need to minimize the general over-treatment of patients with non-aggressive PCa, which account for the majority of PCa cases. In this study we combined N-glycopeptide isolati...
ORGANISM(S): Homo sapiens (Human) 
2014-04-23 | PXD000704 | Pride
Human Prostate Swath Glycoproteome 
ProteomicsUnraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts
Resistance to androgen deprivation therapies leads to metastatic castration-resistant prostate cancer (mCRPC) of adenocarcinoma (AdCa) origin that can transform to emergent aggressive variant prostate cancer (AVPC) which has neuroendocrine (NE)-like features. To this end, we used LuCaP patient-deriv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-09 | MSV000092139 | MassIVE
ProteomicsUnraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts
Resistance to androgen deprivation therapies leads to metastatic castration-resistant prostate cancer (mCRPC) of adenocarcinoma (AdCa) origin that can transform to emergent aggressive variant prostate cancer (AVPC) which has neuroendocrine (NE)-like features. To this end, we used LuCaP patient-deriv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-09 | MSV000092137 | MassIVE
ProteomicsRET Kinase Inhibition in Neuroendocrine Prostate Cancer, part 1
Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD012970 | Pride
Ret Prostate cancer Kinase Phosphoproteomics 
TranscriptomicsLineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity
We used RNA-seq to compare the expression profiles of mouse prostate tumors originated from epithelial basal cells to those originated from luminal cells. We next generated expression signatures for both basal and luminal origin tumors by comparison of tumor samples to their respective controls. By ...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-39509 | biostudies-arrayexpress
TranscriptomicsThe hypoxia marker pimonidazole reflects a transcriptional program associated with aggressive prostate cancer.
We aimed to investigate the transcriptional program associated with pimonidazole staining in prostate cancer. A pimonidazole gene signature was identified that showed positive correlation to Ki67 labeling index, indicating increased proliferation in pimonidazole positive tumors. A positive correlati...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-55935 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of the prostate biopsy samples from African American and European American prostate cancer patients
Prostate cancer (PCa) tends to be more aggressive and lethal in African Americans (AA) compared to European Americans (EA). To further understand the thebiological risk factors associated with PCa disparities observed in AA and EA patients, we performed microRNA profiling using Agilent Human miRNA a...
ORGANISM(S): Homo sapiens 
2015-07-27 | E-GEOD-64318 | biostudies-arrayexpress
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