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TranscriptomicsTranscription profiling of human thyrocytes stably expressing wild type RET/PTC1 oncogene or RET/PTC1 carrying Y451F mutation and parental thyrocytes
Mass populations of thyrocytes stably expressing wild type RET/PTC1 oncogene or RET/PTC1 carrying Y451F mutation and parental thyrocytes were used for hybridization on Affymetrix HG-U133A and HG-U133B chips. For each cell condition were generated two different targets (indicated as two different sam...
ORGANISM(S): Homo sapiens 
2005-09-30 | E-MEXP-429 | biostudies-arrayexpress
TranscriptomicsGenes affected by Ret activation during estrogen stimulation or inhibition in MCF7/Aro cells
Endocrine therapy is the main therapeutic option for patients with estrogen receptor alpha positive (ER+) breast cancer. Nevertheless, most of them become estrogen-independent and relapse after the treatment. Ret is a tyrosine kinase receptor that shows elevated expression levels in ER+ human breast...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-41405 | biostudies-arrayexpress
TranscriptomicsGDNF-RET signaling as a target in aromatase inhibitor resistant breast cancers
Understanding the complex molecular mechanisms underlying resistance to endocrine therapy is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancers. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) signaling via the receptor tyros...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3662 | biostudies-arrayexpress
GenomicsDrugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. We provide further evidence that current anti-RET drugs may not be potent enough to induce ...
EGAS00001002335 | EGA
TranscriptomicsTranscription profiling of human tumor cell line TPC-1 treated with siRNAs targetting RET mRNA and the RET/PTC1 junction
Genomic rearrangements leading to intragenic gene fusion are mainly found in some types of haematopoietic malignancies and sarcomas. Recently they have been described also in carcinomas such as the papillary thyroid histotype (60%-70%) and the Hürthle thyroid tumours (58%). The presence of junction ...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-TABM-746 | biostudies-arrayexpress
ProteomicsDual targeting of RET and SRC synergizes in RET fusion-positive cancer cells
RET fusions (e.g., with KIF5B, CCDC6, and NCOA4) drive subsets of non-small cell lung cancer (NSCLC) and papillary thyroid carcinoma (PTC). Despite improvements in precision therapy using selective RET tyrosine kinase inhibitors (TKIs), resistance occurs and is often driven by RET-independent bypass...
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD063113 | Pride
Phosphoproteomics Lung cancer Expression proteomics Thyroid cancer Kinase inhibition Src Ret 
ProteomicsPhospho-proteomic characterization of CCDC6-RET
Here we show that a CCDC6-RET fusion product, a driver and therapeutic target in lung and thyroid cancers, is a highly active dimeric kinase in solution. Time-resolved mass spectrometry analysis together with a robust biochemical and biophysical characterization reveal the autophosphorylation kineti...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD053907 | Pride
Ccdc6 Phosphorylation Ret 
TranscriptomicsRNA-seq of human neuroblastoma cell lines where RET is knocked out
ALK is driving neuroblastoma (NB) and RET has been shown to be a downstream target of ALK signaling in NB. To get a better understanding of the role of RET in NB, the gene was knocked out in SKNAS cell lines.
ORGANISM(S): Homo sapiens 
2021-04-14 | E-MTAB-10032 | biostudies-arrayexpress
TranscriptomicsParkinson's disease-associated DJ-1 is required for the expression of GDNF receptor Ret in human neuroblastoma cells
DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. To explore DJ-1-mediated transcriptional control in Parkinsonâ??s disease (PD), we generated human neuroblastoma cells with inducible knock-down of DJ-1 expression. We then...
ORGANISM(S): Homo sapiens 
2010-04-28 | E-GEOD-17204 | biostudies-arrayexpress
TranscriptomicsscRNAseq of Mus musculus ileum samples with RET melanoma against non-xenograft mice controls
Compare cell type proportion and gene expression between 3 mice with RET and 3 mice control
ORGANISM(S): Mus musculus 
2021-12-26 | E-MTAB-11242 | biostudies-arrayexpress
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