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ProteomicsPhospho-proteomic characterization of CCDC6-RET
Here we show that a CCDC6-RET fusion product, a driver and therapeutic target in lung and thyroid cancers, is a highly active dimeric kinase in solution. Time-resolved mass spectrometry analysis together with a robust biochemical and biophysical characterization reveal the autophosphorylation kineti...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD053907 | Pride
Ccdc6 Phosphorylation Ret 
UnknownOncogenic Role and Drug Resistance Effect of CCDC6 in iCCA: Potential Strategies for Targeted Intervention.
Not available
S-EPMC12489175 | biostudies-literature
UnknownFBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.
Not available
S-EPMC4494967 | biostudies-literature
UnknownHigh expression of CCDC6 in relation to unfavorable outcome and immune cells infiltration in hepatobiliary carcinoma.
Not available
S-EPMC9516016 | biostudies-literature
UnknownCCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer.
Not available
S-EPMC6381716 | biostudies-literature
UnknownCCDC6 Immunostaining in Conjunction with the Rad51 HRD Assay May Expand PARPi Treatment Eligibility in Patients with HGSOC.
Not available
S-EPMC12833555 | biostudies-literature
UnknownThe tumour suppressor CCDC6 is involved in ROS tolerance and neoplastic transformation by evading ferroptosis.
Not available
S-EPMC8605351 | biostudies-literature
TranscriptomicsGene expression changes induced by transgenic expression of CCDC6-RET or BRAF(V600E) oncogenes in zebrafish thyroid tumors [Zebrafish RET vs BRAF adult tumors]
We used RNAseq to examine gene expression changes in thyroid tumors arising in transgenic zebrafish engineered to expression human CCDC6-RET or BRAF(V600E) oncogenes
ORGANISM(S): Danio rerio 
2022-03-23 | GSE199023 | GEO
UnknownLoss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage.
Not available
S-EPMC3360053 | biostudies-literature
UnknownThe cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS.
Not available
S-EPMC4353705 | biostudies-literature
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