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Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
Breast cancer outcome is highly variable. Whether inadvertent exposure to environmental xenobiotics evokes a biological response promoting cancer aggressiveness and a higher probability of tumor recurrence remains unknown. To determine specific molecular alterations, which arise in high-risk breast ...
ORGANISM(S): Homo sapiens 
Fungal effectors are key determinants of disease development, promoting pathogen growth and spreading in plant tissues. In the wheat/Fusarium graminearum (Fg) interaction determining the Fusarium Head Blight disease (FHB), the molecular bases of Fg aggressiveness remain widely unknown. The aim of th...
ORGANISM(S): Fusarium graminearum Triticum aestivum (Wheat) 
2020-01-13 | PXD015139 | Pride
Peripheral positioning of lysosomes supports melanoma aggressiveness
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD042007 | Pride
Peripheral positioning of lysosomes supports melanoma aggressiveness
Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators [ChIP-seq]
Leukemia aggressiveness is driven by chromatin remodeling and expression changes of core regulators [RNA-seq]
This SuperSeries is composed of the following subset Series: GSE41971: In vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [NanoString] GSE41972: In vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [Affymetrix] Refer to individual Serie...
ORGANISM(S): Homo sapiens 
Triangular Correlation (TrC) between cancer aggressiveness, cell uptake capability and cell deformability
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