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UnknownMolecular dynamics simulation of the follicle-stimulating hormone receptor. Understanding the conformational dynamics of receptor variants at positions N680 and D408 from in silico analysis.
Follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) and a prototype of the glycoprotein hormone receptors subfamily of GPCRs. Structural data of the FSHR ectodomain in complex with follicle-stimulating hormone suggests a "pull and lift" activation mechanism that trigg...
S-EPMC6248991 | biostudies-literature
UnknownMicropulse laser for persistent optic disc pit maculopathy. A case report.

Purpose

Optic disc pits (ODP) are rare and congenital anomalies of the optic disc, sometimes remaining asymptomatic. However, serous macular detachment or optic disc maculopathy is the most common complication, causing significant visual deterioration, without a current consensus about treat...
S-EPMC5956721 | biostudies-literature
UnknownFrequency of the T307A, N680S, and -29G>A single-nucleotide polymorphisms in the follicle-stimulating hormone receptor in Mexican subjects of Hispanic ancestry.

Background

FSHR SNPs may influence the ovarian sensitivity to endogenous and exogenous FSH stimulation. Given the paucity of data on the FSHR c.919A > G, c.2039A > G and - 29G > A SNPs in Hispanic population, we here analyzed their frequency distribution in Mexican mestizo women.

Methods<...

S-EPMC6195735 | biostudies-literature
UnknownIn Vivo and In Silico Studies of the Hepatoprotective Activity of Tert-Butylhydroquinone.
Tert-butylhydroquinone (TBHQ) is a synthetic food antioxidant with biological activities, but little is known about its pharmacological benefits in liver disease. Therefore, this work aimed to evaluate TBHQ during acute liver damage induced by CCl4 (24 h) or BDL (48 h) in Wistar ra...
S-EPMC10779046 | biostudies-literature
UnknownThyroid hormones and breast cancer association according to menopausal status and body mass index.

Background

Thyroxine (T4) has been positively associated with tumor cell proliferation, while the effect of triiodothyronine (T3) on cell proliferation has not been well-established because it differs according to the type of cell line used. In Mexico, it has been reported that 14.5% of adul...
S-EPMC6085630 | biostudies-literature
UnknownStructural insights from a novel invertebrate triosephosphate isomerase from Litopenaeus vannamei.
Triosephosphate isomerase (TIM; EC 5.3.1.1) is a key enzyme involved in glycolysis and gluconeogenesis. Glycolysis is one of the most regulated metabolic pathways, however little is known about the structural mechanisms for its regulation in non-model organisms, like crustaceans. To understand the s...
S-EPMC5071168 | biostudies-literature
UnknownEffectiveness of a Malaria Surveillance Strategy Based on Active Case Detection during High Transmission Season in the Peruvian Amazon.
Background: Faced with the resurgence of malaria, malaria surveillance in the Peruvian Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy (LM) as reactive measure in communities with an unusual high number of cases during high transmission season ...
S-EPMC6314008 | biostudies-literature
UnknownWarning Before a Fight: The Role of Distance and Ritualized Agonistic Behaviors in Minimizing Aggression in the Jamaican Fruit Bat.
In many vertebrates, ritualized behaviors serve to settle conflicts while minimizing the risk of injury. The Jamaican fruit bat (Artibeus jamaicensis) is a polygynous species that roosts in caves, where dominant males form and defend harems by displaying agonistic behaviors against satellite ...
S-EPMC12561160 | biostudies-literature
UnknownInhibition of the CYP Enzymatic System Responsible of Heterocyclic Amines Bioactivation by an Asclepias subulata Extract.
Asclepias subulata plant extract has previously demonstrated antiproliferative activity and antimutagenicity against heterocyclic aromatic amines (HAAs) commonly found in cooked meat. The objective of this work was to evaluate the in vitro ability of an ethanolic extract from the medicinal pl...
S-EPMC10305697 | biostudies-literature
UnknownRole of Cysteine Residues in the Carboxyl-Terminus of the Follicle-Stimulating Hormone Receptor in Intracellular Traffic and Postendocytic Processing.
Posttranslational modifications occurring during the biosynthesis of G protein-coupled receptors include glycosylation and palmitoylation at conserved cysteine residues located in the carboxyl-terminus of the receptor. In a number of these receptors, these modifications play an important role in rec...
S-EPMC4951517 | biostudies-literature
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