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UnknownPredicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning.
Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which ende...
S-EPMC8318275 | biostudies-literature
UnknownMapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000-2018.

Background

Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Prog...
S-EPMC9760541 | biostudies-literature
UnknownIn-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization.
The aberrant expression of aldo keto reductases (AKR1B1 & AKR1B10) has been extensively studied in different types of cancer especially the colon cancer but a very few studies have yet been reported regarding the discovery of inhibitors for the treatment of colon cancer by targeting these isozymes. ...
S-EPMC9612481 | biostudies-literature
UnknownEvolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.

Background

Cisplatin (CDDP) is a mainstay treatment for advanced head and neck squamous cell carcinomas (HNSCC) despite a high frequency of innate and acquired resistance. We hypothesised that tumours acquire CDDP resistance through an enhanced reductive state dependent on metabolic rewiring...
S-EPMC10205814 | biostudies-literature
UnknownManagement of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study.

Objectives

To assess the compliance of Asian intensive care units and hospitals to the Surviving Sepsis Campaign's resuscitation and management bundles. Secondary objectives were to evaluate the impact of compliance on mortality and the organisational characteristics of hospitals that were a...
S-EPMC3113333 | biostudies-literature
Unknown2023 Canadian Surgery Forum: Sept. 20-23, 2023.
Not available
S-EPMC10718225 | biostudies-literature
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.

Importance

Rheumatic heart disease (RHD) remains a public health issue in low- and middle-income countries (LMICs). However, there are few large studies enrolling individuals from multiple endemic countries.

Objective

To assess the risk and predictors of major patient-important clinic...
S-EPMC11154374 | biostudies-literature
UnknownConservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial.

Importance

Supplemental oxygen is frequently given to patients in intensive care units (ICUs); however, there is insufficient evidence to guide its therapeutic use and to minimize the potential harm caused by administering too little or too much.

Objective

To determine whether reducin...
S-EPMC12163715 | biostudies-literature
UnknownGlobal Burden of Cardiovascular Diseases and Risks, 1990-2022.
Not available
S-EPMC7615984 | biostudies-literature
UnknownVasopressor use after noncardiac surgery: an international observational study.

Background

Hypotension after major noncardiac surgery is associated with increased morbidity, mortality, and costs, and is often treated with postoperative vasopressor infusions. The frequency of administration in the postoperative period is unknown.

Methods

This international prospec...
S-EPMC12799376 | biostudies-literature
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