Sort   by:  
 Page size 
ProteomicsInvestigative needle core biopsies support multimodal deep-data generation in glioblastoma
Glioblastoma (GBM) is a primary brain cancer with an abysmal prognosis with few effective therapies. The ability to investigate the tumor microenvironment before and during treatment would greatly enhance both our understanding of disease response and progression, as well as the delivery and impact ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046857 | Pride
Stereotactic biopsy Multi-omics Single cell sequencing Metabolomics Sampling variance Glioblastoma Immunopeptidomics Spatial 
ProteomicsDeciphering the immunopeptidome in vivo reveals novel tumor antigens
Effective immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex Class I (MHC-I). Recent developments in proteomics have improved the identification of peptides that are naturally presented by MHC-I, collectively known as the “immunopeptidome”....
ORGANISM(S): Mus musculus (Mouse) 
2022-06-20 | PXD033232 | Pride
H2-kb In vivo Ligandomics Mhc Immunopeptidomics Antigen presentation 
ProteomicsComplex I Inhibition combined with TLR Activation in the Breast Tumor Microenvironment Educates Cytotoxic Neutrophils
Neutrophils have emerged as diverse regulators of tissue states, displaying functions in both the resolution and promotion of tissue inflammation. While neutrophils have widely been associated with tumor promotion, immune suppression, and poor patient outcome, we provide evidence to support direct t...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-04 | PXD054085 | Pride
Breast cancer Secretory granules Complex i inhibition Tlr receptors Nf-kb signaling Oxidative stress Neutrophils 
ProteomicsUncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT
Dysregulation of intracellular signaling networks underpins cancer. Yet, resolving signaling networks within distinct or rare cell types in cancer in vivo has been unattainable. Here we develop INSIGHT by integrating cell sorting with mass spectrometry to enable quantitative phosphoproteomics and pr...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-27 | PXD056965 | Pride
Sort   by:  
 Page size