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TranscriptomicsTranscription profiling of mouse keratinocytes expressing AhR to investigate inflammatory responses
Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to provoke inflammatory and/or allergic disorders including asthma, rhinitis and dermatitis. The molecular mechanisms of this PAH-mediated inflammation remain to be clarified. Previous studies imp...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2955 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis reveals endogenous aryl hydrocarbon receptor regulation is highly associated with eicosanoid synthesis and tumor necrosis factor activity in MCF-7 cancer cells
Background: The Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is activated by xenobiotic chemicals that function as AHR ligands. The response to xenobiotic AHR ligands is toxicity and the induction of drug metabolizing enzymes. The impact of AHR knockdown on gene e...
ORGANISM(S): Homo sapiens 
2014-06-20 | E-GEOD-52036 | biostudies-arrayexpress
ProteomicsProteome and Phosphoproteome of AhR-dependent non-genomic signaling in endotoxin-activated macrophages
Emerging studies revealed an immunomodulatory role of the Aryl hydrocarbon receptor (AhR), a receptor sensing environmental contaminants, and involved in their detoxification. Besides its function as a transcription factor, AhR can participate in non-genomic signaling through ubiquitination and phos...
ORGANISM(S): Homo sapiens (Human) 
2021-03-30 | PXD020770 | Pride
Macrophages Human Proteome Ahr Phosphoproteome Lc-ms/ms 
TranscriptomicsThe Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Liver
The aryl hydrocarbon receptor (AHR) is a widely-expressed ligand-dependent transcription-factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Indeed, AHR-null mice are refractory to the physiological effects of dioxin-exposure. Although some mechanistic aspects ...
ORGANISM(S): Mus musculus 
2009-09-21 | E-GEOD-15858 | biostudies-arrayexpress
TranscriptomicsThe Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Kidney
The aryl hydrocarbon receptor (AHR) is a widely-expressed ligand-dependent transcription-factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Indeed, AHR-null mice are refractory to the physiological effects of dioxin-exposure. Although some mechanistic aspects ...
ORGANISM(S): Mus musculus 
2009-09-21 | E-GEOD-15857 | biostudies-arrayexpress
GenomicsAHR Ligands Suppress IgG-triggered Signaling in Human PBMCs
AHR Ligands Suppress IgG-triggered Signaling in Human PBMCs
PRJNA1458223 | ENA
TranscriptomicsEnvironmental factors transmitted by aryl hydrocarbon receptor influence severity of psoriatic skin inflammation [RNA-Seq]
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanism is unknown. Here we show that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis. AhR-activati...
ORGANISM(S): Homo sapiens 
2014-06-11 | E-GEOD-47944 | biostudies-arrayexpress
GenomicsEndothelial sensing of AHR ligands regulates intestinal barrier immunity [AHR KO RNA-seq]
Endothelial sensing of AHR ligands regulates intestinal barrier immunity [AHR KO RNA-seq]
PRJNA932742 | ENA
TranscriptomicsRole of AhR in thymocyte emigration in vivo
Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the p...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild-type or genetically deleted AHRs were treated with corn oil vehicle or TCDD reveals aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the complete spectrum of AHR-dependent genes in male adult liver using expression arrays to contrast mRNA profiles in Ahr-null ...
ORGANISM(S): Mus musculus 
2008-11-13 | E-GEOD-10082 | biostudies-arrayexpress
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