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ProteomicsDiscovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
PKMYT1 has recently emerged as a compelling therapeutic target for precision cancer therapy due to its synthetic lethality with oncogenic alterations such as CCNE1 amplification and mutations in FBXW7 and PPP2R1A. Current small molecule PKMYT1 inhibitors face limitations, such as insufficient molecu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-28 | PXD062889 | Pride
Protac Pkmyt1 Synthetic lethality Ai-generation 
TranscriptomicsChIP for H3K27me3 in Murine ES Cells: wild type and Ring1B-/- cells
Native ChIP on chip for H3K27me3 in murine ES cells comparing WT and Ring1B-/- cells. Paper Abstract: How polycomb group proteins repress gene expression in vivo is not known. Whilst histone modifying activities of the polycomb repressive complexes have been studied extensively, in vitro data has su...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-20213 | biostudies-arrayexpress
UnknownDiscovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation.
Not available
S-EPMC12663101 | biostudies-literature
UnknownA cluster-randomized controlled trial of a nurse-led artificial intelligence assisted prevention and management for delirium (AI-AntiDelirium) on delirium in intensive care unit: Study protocol.
Not available
S-EPMC10903907 | biostudies-literature
UnknownA multimodal generative AI copilot for human pathology.
Not available
S-EPMC11464372 | biostudies-literature
UnknownA generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial.
Not available
S-EPMC12353801 | biostudies-literature
UnknownGSP-AI: An AI-Powered Platform for Identifying Key Growth Stages and the Vegetative-to-Reproductive Transition in Wheat Using Trilateral Drone Imagery and Meteorological Data.
Not available
S-EPMC11462051 | biostudies-literature
UnknownPD-1/PD-L1 Cancer Immunotherapeutics Reshape Tumor Microenvironment - Clinical Evidence and Molecular Mechanisms for AI-based Precision Medicine.
Not available
S-EPMC12532714 | biostudies-literature
UnknownArtificial intelligence suppression as a strategy to mitigate artificial intelligence automation bias.
Not available
S-EPMC10531198 | biostudies-literature
TranscriptomicsMurine Embryonic Stems Cells: H3K27me3 in Undifferentiated (UD) and Day 3 (D3) differentiated ES cells
ChIP on chip for H3K27me3 in murine ES cells comparing Undifferentiated and Day 3 differentiated. Paper Abstract: How polycomb group proteins repress gene expression in vivo is not known. Whilst histone modifying activities of the polycomb repressive complexes have been studied extensively, in vitro...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-20201 | biostudies-arrayexpress
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