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TranscriptomicsAnalysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62966 | biostudies-arrayexpress
TranscriptomicsEstrogen deprivation alters epigenetic modifications in breast cancer cells - HOXC10 loss in endocrine resistance
Postmenopausal breast cancer patients benefit from aromatase inhibitors (AIs) that reduce the levels of estrogens critical for the growth of estrogen receptor (ER)-positive tumors. Unfortunately, many tumors are resistant to AI, and we are only beginning to understand the complex mechanisms underly...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-39783 | biostudies-arrayexpress
UnknownhECA v2.0: an AI-ready ensemble cell atlas of single-cell RNA and ATAC sequencing data.
Not available
S-EPMC12852668 | biostudies-literature
UnknownAI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography.
Not available
S-EPMC6825537 | biostudies-literature
UnknownLLM evaluation for thyroid nodule assessment: comparing ACR-TIRADS, C-TIRADS, and clinician-AI trust gap.
Not available
S-EPMC12515656 | biostudies-literature
TranscriptomicsLiver X receptor beta is the dominant LXR subtype in skeletal muscle
Liver X receptors (LXRs) are important regulators of cholesterol, lipid and glucose metabolism and have been extensively studied in liver, macrophages and adipose tissue. However, their role in skeletal muscle is not yet fully elucidated and the functional role of each of the LXRM-NM-1 and LXRM-NM-2...
ORGANISM(S): Mus musculus 
2010-03-30 | E-GEOD-13192 | biostudies-arrayexpress
UnknownA benchmark of expert-level academic questions to assess AI capabilities.
Not available
S-EPMC12851929 | biostudies-literature
TranscriptomicsRNA-seq analysis of human hepatocyte Huh7 cells transfected with CRISPR/(d)Cas9 plasmids for transcriptional activation of APOA1 and PON1
The aim of the present study was to obtain and characterize an in vitro model for endogenous APOA1 and PON1 long-time up-regulation in hepatocytes that can be further used to decipher the mechanism of their protective action. Cultured human hepatocytes (HuH-7 cell line) were transfected with CRISPR/...
ORGANISM(S): Homo sapiens 
2026-07-03 | E-MTAB-17152 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse LXRalpha null, LXRbeta null mutants reveals liver X receptor beta is the dominant LXR subtype in skeletal muscle
Liver X receptors (LXRs) are important regulators of cholesterol, lipid and glucose metabolism and have been extensively studied in liver, macrophages and adipose tissue. However, their role in skeletal muscle is not yet fully elucidated and the functional role of each of the LXRalpha (NR1H3) and LX...
ORGANISM(S): Mus musculus 
2009-10-01 | E-MTAB-61 | biostudies-arrayexpress
UnknownStructural insights into the N-terminal APHB domain of HrpA: mediating canonical and i-motif recognition.
Not available
S-EPMC11014265 | biostudies-literature
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