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GenomicsThe Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing [ChIP-Seq]
G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual inter...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-46536 | biostudies-arrayexpress
TranscriptomicsThe Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing [RNA-Seq]
G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual inter...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-49669 | biostudies-arrayexpress
ProteomicsSETDB1-Dependent Modulation of the TGFb-induced Secretome in Duchenne Muscular Dystrophy: The Role of EMILIN1
Duchenne Muscular Dystrophy (DMD) is a severe X-linked muscle-wasting disorder characterized by chronic inflammation, progressive fibrosis, and impaired muscle regeneration. The TGFb pathway is overactivated in DMD and it sustains the accumulation of extracellular matrix (ECM), contributing to fibro...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD068544 | Pride
Emilin1 Dmd Setdb1 Tgf Secretome Myotube 
GenomicsCanonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation [ChIP-seq]
The histone 3 lysine 9 (H3K9)-specific methyltransferase (KMT) Setdb1 is essential for both stem cell pluripotency and terminal differentiation of different cell types. To shed light on Setdb1 role(s) in these mutually exclusive processes, we used mouse skeletal myoblasts as a model of terminal diff...
ORGANISM(S): Mus musculus 
2016-02-01 | E-GEOD-65493 | biostudies-arrayexpress
GenomicsAnalysis of genome wide H3K9me3 levels in control and ORCA knockdown cells
Origin Recognition Complex Associated (ORCA) associates with repressive chromatin environments. We carried out H3K9me3 ChIP-seq to determine the affect of ORCA's loss on this repressive mark. Towards this end, we cultured U2OS osteosarcoma cells, performed control and ORCA knockdowns using siRNAs an...
ORGANISM(S): Homo sapiens 
2015-04-28 | E-GEOD-68129 | biostudies-arrayexpress
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