Sort   by:  
 Page size 
ProteomicsSETDB1-Dependent Modulation of the TGFb-induced Secretome in Duchenne Muscular Dystrophy: The Role of EMILIN1
Duchenne Muscular Dystrophy (DMD) is a severe X-linked muscle-wasting disorder characterized by chronic inflammation, progressive fibrosis, and impaired muscle regeneration. The TGFb pathway is overactivated in DMD and it sustains the accumulation of extracellular matrix (ECM), contributing to fibro...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD068544 | Pride
Emilin1 Dmd Setdb1 Tgf Secretome Myotube 
GenomicsEMILIN1 suppresses cell proliferation by inactivating Aurora Kinase and cell cycle regulator in head and neck squamous cell carcinoma
EMILIN1 suppresses cell proliferation by inactivating Aurora Kinase and cell cycle regulator in head and neck squamous cell carcinoma
PRJNA1066749 | ENA
TranscriptomicsEMILIN1 suppresses cell proliferation by inactivating Aurora Kinase and cell cycle regulator in head and neck squamous cell carcinoma
The extracellular matrix (ECM) proteins play an important role in the physiological and pathological processes of tumor development and progression. EMILIN1 (Elastic Microfibril Interface Located ProteIN-1), a homotrimeric ECM glycoprotein, has been reported to be associated with cell adhesion and m...
ORGANISM(S): Homo sapiens 
2025-01-15 | GSE253677 | GEO
ProteomicsEMILIN1 emerges as a SETDB1-dependent modulator of the secretome in Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is an incurable muscle-wasting disorder characterized by chronic membrane damage, inflammation, and progressive fibrosis. Fibrosis in DMD is driven by sustained TGF signaling, which promotes extracellular matrix (ECM) accumulation. We previously showed that SETDB1 s...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD074360 | Pride
Tgfbeta Muscle fibrosis Human muscular dystrophy Muscle secretome Duchenne muscular dystrophy 
UnknownEMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis.
Not available
S-EPMC9748297 | biostudies-literature
UnknownLoss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice.
Not available
S-EPMC10771445 | biostudies-literature
UnknownTGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease.
Not available
S-EPMC4107327 | biostudies-literature
UnknownInhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model.
Not available
S-EPMC5350168 | biostudies-literature
UnknownNeutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity.
Not available
S-EPMC5225433 | biostudies-literature
UnknownPooled analyses of the associations of polymorphisms in the GRK4 and EMILIN1 genes with hypertension risk.
Not available
S-EPMC3360431 | biostudies-literature
Sort   by:  
 Page size