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TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
Unknownp75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.
Not available
S-EPMC2593496 | biostudies-literature
ProteomicsDefining blood-induced microglia functions in neurodegeneration through multiomic profiling
Blood protein extravasation through a disrupted blood–brain barrier and innate immune activation are hallmarks of neurological diseases and emerging therapeutic targets. However, how blood proteins polarize innate immune cells remains largely unknown. Here, we established an unbiased blood-innate im...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-02 | PXD021230 | Pride
Neuroinflammation Itaconate Complement Fibrinogen Macrophages Ros Oxidative stress Microglia Transcriptomics 
UnknownP2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation.
Not available
S-EPMC1323158 | biostudies-literature
UnknownIn vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain.
Not available
S-EPMC8259313 | biostudies-literature
UnknownBrain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration.
Not available
S-EPMC387376 | biostudies-literature
UnknownAcute vascular disruption and aquaporin 4 loss after stroke.
Not available
S-EPMC2753985 | biostudies-literature
UnknownIn vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target.
Not available
S-EPMC8502531 | biostudies-literature
UnknownBlood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma.
Not available
S-EPMC7919853 | biostudies-literature
UnknownFractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy.
Not available
S-EPMC5222852 | biostudies-literature
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