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MetabolomicsPseudorabies Virus Triggers Ferritinophagy-Mediated Ferroptosis and Neuroinflammation in Viral Encephalitis

Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, primarily infects pigs and poses a significant threat to the swine industry. In recent years, emerging PRV variants have been reported to infect humans, predominantly causing encephalitis. Ferroptosis is a recently identified...

2026-04-17 | MTBLS12373 | MetaboLights
MetabolomicsWalnut protein hydrolysate alleviates neuroinflammation and memory impairment in naturally aged mice via a gut microbiota-metabolite-neuroinflammation axis
This study investigated age-associated alterations in the serum metabolome and the metabolic effects of walnut protein hydrolysate (WPH) supplementation in naturally aged mice. Male C57BL/6J mice at different ages (2-month, 10-month and 18-month) were used to characterize metabolic changes associate...
2026-09-04 | MTBLS15363 | MetaboLights
MetabolomicsA gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI

A gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI


Probiotic L. reuteri attenuates neuroinflammation and anxiety symptoms through gut-brain axis via a novel metabolite 20-HETE in blast-induced traumatic brain injury

2026-07-17 | MTBLS15072 | MetaboLights
MetabolomicsMicrobial-derived Hyodeoxycholic Acid Ameliorates Painful Diabetic Neuropathy by Modulating Dorsal Root Ganglion TLR4-Mediated Neuroinflammation Signaling Pathway

BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...

2026-08-24 | MTBLS12087 | MetaboLights
TranscriptomicsSemaglutide Attenuates Neuroinflammation in Mice
Bulk RNA sequencing of the hippocampus from mice treated with semaglutide or vehicle control prior to lipopolysaccharide (LPS)-induced neuroinflammation.
ORGANISM(S): Mus musculus 
2026-07-01 | E-MTAB-17123 | biostudies-arrayexpress
TranscriptomicsGene expression changes in LPS-induced neuroinflammation
Neuroinflammation plays a role in the progression of several neurodegenerative disorders. We used a lipolysaccharide (LPS) model of neuroinflammation to characterize the gene expression changes underlying the inflammatory and behavioral effects of neuroinflammation. A single intracerebroventricular ...
ORGANISM(S): Mus musculus 
2008-11-01 | E-GEOD-12284 | biostudies-arrayexpress
ProteomicsSpermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model
Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been found to be another important feature contributing to AD progression. Therefo...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-04 | PXD034638 | Pride
Neuroinflammation Autophagy Phagocytosis Alzheimer’s disease Dietary supplement Spermidine Microglia Liquid chromatography tandem mass spectrometry 
TranscriptomicsTranscription profiling of brains from adult and aged mice injected with E. coli LPS to study the exaggerated neuroinflammation in aged mice following activation of peripheral innate immune system.
Acute cognitive impairment (i.e., delirium) is common in elderly emergency department patients and frequently results from infections that are unrelated to the central nervous system. Since activation of the peripheral innate immune system induces brain microglia to produce inflammatory cytokines th...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3253 | biostudies-arrayexpress
GenomicsSemaglutide Attenuates Neuroinflammation in Mice
Semaglutide Attenuates Neuroinflammation in Mice
PRJEB113706 | ENA
GenomicsSemaglutide Attenuates Neuroinflammation in Mice
Semaglutide Attenuates Neuroinflammation in Mice
PRJEB110918 | ENA
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