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MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsTo explore the role of circulating oxidized lipids in the progression and prognosis of SA-AKI by means of histochemistry

Background: Plasma oxidized lipids are intimately linked to immune regulation as bioactive mediators. However, it is not clear whether they are related to the progression of sepsis-associated acute kidney injury (SA-AKI) and the effect of continuous renal replacement therapy (CRR...

2024-12-16 | MTBLS11695 | MetaboLights
TranscriptomicsHIF orchestrated metabolic shift confers protection against Acute Kidney Injury (AKI)
Renal hypoxia is widespread in acute kidney injury (AKI) of various aetiologies. Hypoxia adaptation, conferred through the hypoxia-inducible factor (HIF), appears to be insufficient. Here we show that HIF activation in renal tubules through Pax8-rtTA-based inducible knockout of von Hippel-Lindau pro...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-44925 | biostudies-arrayexpress
TranscriptomicsRole of miRNAs in acute kidney injury recovery induced by mesenchymal stromal cells and derived extracellular vesicles.
Phenotypic changes induced by extracellular vesicles (EVs) have been implicated in the recovery of acute kidney injury (AKI) induced by mesenchymal stromal cells (MSCs). miRNAs are potential candidates for cell reprogramming towards a pro-regenerative phenotype. The aim of the present study was to e...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-59958 | biostudies-arrayexpress
MetabolomicsThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST001855 | MetabolomicsWorkbench
MetabolomicsThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST001856 | MetabolomicsWorkbench
ProteomicsComprehensive Landscape of SA-AKI Revealed by Integrated Proteomics and Metabolomics Analysis
Sepsis-associated acute kidney injury (SA-AKI) is a severe and life-threatening condi-tion with high morbidity and mortality among emergency patients, and it poses a sig-nificant risk of chronic renal failure. Clinical treatments for SA-AKI remain reactive and non-specific, lacking effective diagnos...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044371 | Pride
Sa-aki  proteomics  metabolomics  biomarker  mitochondrial dysfunction 
TranscriptomicsGene Expression Profiles of Transplanted Kidneys from Deceased Donors with Severe Acute Kidney Injury
One and four month formalin-fixed paraffin embedded biopsies from 48 kidney transplant recipients (24 AKI donors, 24 non-AKI) underwent global gene expression profiling using DNA microarrays (96 arrays). At one month, there were 898 differentially expressed genes in the AKI group (p-value <0.005; FD...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-61739 | biostudies-arrayexpress
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
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