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TranscriptomicsTranscription profiling of mouse wild-type and B cell-specific TAK1-deficient B cells to elucidate how TAK1 regulates BCR-mediated proliferative response
BCR-induced gene expression profile in wild-type and B cell-specific TAK1-deficient B cells; to elucidate how TAK1 regulates BCR-mediated proliferative response Experiment Overall Design: Purified splenic B cells (CD43 negative) were treated with or without anti-IgM (20 micloG/mL) for 4 h. Total RNA...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3065 | biostudies-arrayexpress
TranscriptomicsExpression data from neutrophils from wild-type and Jdp2-/- mice
Jdp2 is a member of the AP-1 family and suppresses histone acetyltransferase activity. We used microarrays to examine the gene expression pattern of neutrophil form Jdp2-/- mice. Bone marrow CD11b+Ly6Clo Ly6G+ neutrophils form wild-type and Jdp2-/-mice were sorted by FACS, followed by RNA extraction...
ORGANISM(S): Mus musculus 
2012-11-30 | E-GEOD-42063 | biostudies-arrayexpress
TranscriptomicsGene expression data from wild-type and Nlrc5 knockout GM-CSF induced bone marrow dendritic cells infected with Newcastle Disease virus.
Nlrc5 is encoding a Nod-like receptor protein NLRC5/NOD27. To check the involvement of Nlrc5 in antiviral response, we examined gene expression profile in wild-type and Nlrc5 knockout GM-CSF bone marrow macrophage with using microarrays. Bone marrow cells were cultured with GM-CSF and harvested on d...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-22448 | biostudies-arrayexpress
UnknownThe autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy.
Not available
S-EPMC10983954 | biostudies-literature
TranscriptomicsA host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyc...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-16943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse IECS response to flagellin stimulation
Microarray analysis of IECs from Tlr5+/+ and Tlr5–/– mice stimulated with either medium alone or flagellin (1 µg/ml); to elucidate TLR5-mediated immune responses in IECs. Experiment Overall Design: IECs from Tlr5+/+ and Tlr5–/– mice were treated with or without flagellin (1 g/ml) for 4 h...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5112 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muse flagellin stimulated CD11c+ LPCs
Microarray analysis of IECs from Tlr5+/+ and Tlr5–/– mice stimulated with either medium alone or flagellin (1 µg/ml); to elucidate TLR5-mediated immune responses in CD11c+ LPCs Experiment Overall Design: CD11c+ LPCs from Tlr5+/+ and Tlr5–/– mice were treated with or without flagellin (1 ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5113 | biostudies-arrayexpress
Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
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