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ProteomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
AKIRIN2 regulates the import of proteasomes into the nucleus. To analyze AKIRIN2-containing proteasome complexes, we performed co-immunoprecipitation of GST-tagged AKIRIN2, followed by sucrose gradient centrifugation and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027343 | Pride
Akirin2 Crispr/cas9 screen Nuclear import Proteasome Protein degradation 
ProteomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
AKIRIN2 is an essential negative regulator of nuclear protein, including oncogenic transcription factors such as MYC. To identify the mode of AKIRIN2-dependent nuclear protein regulation we performed pulldown and mass spectrometry of V5-tagged AKIRIN2 variants or nuclear GFP control.
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027184 | Pride
Akirin2 Crispr/cas9 screen Nuclear import Proteasome Protein degradation 
GenomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
AKIRIN2 controls the nuclear import of proteasomes in vertebrates
PRJNA662348 | ENA
ProteomicsSystematic analysis of MYC regulators identifies AKIRIN2 as an essential mediator of nuclear proteasome import
AKIRIN2 is an essential negative regulator of MYC protein levels. To test the specificity of AKIRIN2-dependent MYC regulation we performed unbiased protein quantification after inducible AKIRIN2- or Proteasome knockout und identified subsets of proteins accumulating after loss of AKIRIN2, Proteasome...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD021898 | Pride
Inducible cas9 Akirin2 Proteasome 
TranscriptomicsAKIRIN2 controls the nuclear import of proteasomes in vertebrates
Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and temporal regulation of cellular processes. To systematically elucidate such gene regulatory networks, we developed a CRISPR scre...
ORGANISM(S): Homo sapiens 
2021-08-27 | GSE157663 | GEO
Unknownp53-mediated neurodegeneration in the absence of the nuclear protein Akirin2.
Not available
S-EPMC8844820 | biostudies-literature
UnknownDual roles of Akirin2 protein during Xenopus neural development.
Not available
S-EPMC5392563 | biostudies-literature
UnknownAkirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways.
Not available
S-EPMC5361102 | biostudies-literature
UnknownFunction of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells.
Not available
S-EPMC8298264 | biostudies-literature
UnknownThe FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.
Not available
S-EPMC3819372 | biostudies-literature
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