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ProteomicsThe p53 Tumor Suppressor Regulates AKR1B1 Expression, a MetastasisPromoting Gene in Breast Cancer
Alteration of metabolism in cancer cells is a central aspect of the mechanisms that sustain aggressive traits. Aldo-keto reductase 1 B1 (AKR1B1) catalyzes the reduction of several aldehydes to alcohols consuming NADPH. Nevertheless, the ability of AKR1B1 to reduce different substrates renders diffic...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-19 | PXD045048 | Pride
Breast cancer Mitochondria Electron transport chain Aldo-keto reductases Akr1b1 Proteomics P53 Metastasis 
GenomicsAKR1B1 is required for maintaining acute leukemia cell survival by epigenetic silencing of tumor suppressor genes
AKR1B1 is required for maintaining acute leukemia cell survival by epigenetic silencing of tumor suppressor genes
PRJNA1152355 | ENA
GenomicsSMARCA5 deficiency reprograms AKR1B1-mediated endogenous fructose metabolism to eradicate leukemia stem cells in acute myeloid leukemia
SMARCA5 deficiency reprograms AKR1B1-mediated endogenous fructose metabolism to eradicate leukemia stem cells in acute myeloid leukemia
PRJNA901174 | ENA
TranscriptomicsSMARCA5 deficiency reprograms AKR1B1-mediated endogenous fructose metabolism to eradicate leukemia stem cells in acute myeloid leukemia
A significant variation in chromatin accessibility is an epigenetic feature in leukemia cells. However, the regulators and consequences of the chromatin accessibility variations in leukemia remain elusive. Here we identified SMARCA5, a core ATPase of the ISWI chromatin remodeling complex, as the pri...
ORGANISM(S): Homo sapiens 
2023-10-04 | GSE217881 | GEO
GenomicsThe effect of fructose vs glucose supplementation on stable AKR1B1 knockdown in A549 lung cancer cells
The effect of fructose vs glucose supplementation on stable AKR1B1 knockdown in A549 lung cancer cells
PRJNA885776 | ENA
UnknownAKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas.
Not available
S-EPMC8305663 | biostudies-literature
TranscriptomicsAKR1B1 is required for maintaining acute leukemia cell survival by epigenetic silencing of tumor suppressor genes
In order to explore the role of AKR1B1 in gene transcription expression, we established shControl and shAKR1B1_1 in Jurkat cells to down-regulate AKR1B1 expression in Jurkat. We then analyzed gene expression using RNA-seq. Finally, 6 sets of shControl and shAKR1B1_1 data are obtained
ORGANISM(S): Homo sapiens 
2024-12-09 | GSE275641 | GEO
TranscriptomicsThe effect of fructose vs glucose supplementation on stable AKR1B1 knockdown in A549 lung cancer cells
To investigate the cytotoxic effect of AKR1B1 depletion, we induced stable AKR1B1 knockdown via shRNA under different growth conditions (glucose vs fructose) We then performed gene expression profiling analysis using data obtained from RNA-seq of control (non-targeting shRNA) or shAKR1B1 A549 cells ...
ORGANISM(S): Homo sapiens 
2022-10-03 | GSE214505 | GEO
UnknownAKR1B1-dependent fructose metabolism enhances malignancy of cancer cells.
Not available
S-EPMC11618507 | biostudies-literature
UnknownAKR1B1 as a Prognostic Biomarker of High-Grade Serous Ovarian Cancer.
Not available
S-EPMC8834204 | biostudies-literature
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