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ProteomicsATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt
We use HDX-MS to interrogate the AKT1 DrLink conformational changes upon binding AKT1 active site inhibitors A-443654, Capivasertib, and Uprosertib, Akt1 allosteric inhibitor MK-2206, and ADP.
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD039028 | Pride
Akt1 drlink Atp competitive inhibitors Allosteric inhibitors Akt1 Protein kinase b Hdx-ms 
ProteomicsStructure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation
To directly observe the conformational changes in Akt1 3P elicited by PIP 3 binding, we performed HDX-MS analysis of Akt1 3P in the presence of plasma membrane-mimicking liposomes (20% cholesterol, 30% phosphatidylcholine, 15% phosphatidylserine, 35% phosphatidylethanolamine) that contained either 0...
ORGANISM(S): Homo sapiens (Human) 
2021-09-01 | PXD022061 | Pride
Pip3 Akt Lipids Hdx-ms 
ProteomicsHDX-MS analysis of the mechanism of AKT1 inhibitor binding
Analysis of AKT1 inhibitor binding using HDX-MS .
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD032929 | Pride
Hdx-ms Akt1 Akt drlink Akt da 
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